Prof. Madhubala Rentala Ph.D

Prof. Madhubala Rentala

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  1. Pawar H, Puri M, Fischer Weinberger R, Madhubala R, Zilberstein D. The arginine sensing and transport binding sites are distinct in the human pathogen Leishmania. PLoS Negl Trop Dis. 2019 Apr 24;13(4):e0007304. doi: 10.1371/journal.pntd.0007304. eCollection 2019
  2. Bansal R, Sen SS, Muthuswami R, Madhubala R. A Plant like Cytochrome P450 Subfamily CYP710C1 Gene in Leishmania donovani Encodes Sterol C-22 Desaturase and its Over-expression Leads to Resistance to Amphotericin B. PLoS Negl Trop Dis. 2019 Apr 3;13(4):e0007260. doi: 10.1371/journal.pntd.0007260. eCollection 2019
  3. Manhas R, Tandon S, Sen SS, Tiwari N, Munde M, Madhubala R. Leishmania parasites are inhibited by the benzoxaborole AN2690 targeting leucyl-tRNA synthetase Antimicrob Agents Chemother. Jun 25. pii: AAC.00079-18. doi: 10.1128/AAC.00079-18. [Epub ahead of print] 2018
  4. Chadha S, Vijayan R, Gupta S, Munde M, Gourinath S, Madhubala R. Genetic manipulation of Leishmania donovani threonyl tRNA synthetase facilitates its exploration as a potential therapeutic target. PLoS Negl Trop Dis. Jun 13;12 (6):e0006575. doi: 10.1371/journal.pntd.0006575. [Epub ahead of print] 2018
  5. Sanya Chadha, N. Arjunreddy Mallampudi, Debendra K. Mohapatra, and Rentala Madhubala. Genetic Validation of Leishmania donovani Lysyl-tRNA Synthetase shows that It Is Indispensable for Parasite Growth and Infectivity mSphere, Aug 30; 2 (4). pii: e00340-17. doi: 10.1128/mSphereDirect.00340-17. eCollection 2017
  6. Nimisha Mittal, Rohini Muthuswami and Rentala Madhubala The mitochondrial SIR2 related protein 2 (SIR2RP2) impacts Leishmania donovani growth and infectivity pLOS Neglected Tropical Diseases. 11;11(5): e0005590. doi: 10.1371/journal.pntd.0005590, 2017
  7. Ruby Bansal, Himanshu Bhusan Samal, V S Gowri, Shib Sankar Sen, Indira Ghosh and Rentala Madhubala The Cytochrome P450 Complement (CYPome) of Leishmania leads to the discovery of a plant like Cytochrome P450 subfamily CYP710C1 gene. Proceedings of Indain National Science Academy, PINSA, DOI: 10.16943/ptinsa/2017/49026, 2017
  8. Sneha Anand and Rentala Madhubala Twin attributes of tyrosyl tRNA-synthetase of Leishmania donovani: a housekeeping protein transla¬tion enzyme and a mimic of host CXC chemokine J Biol Chem. 2016 Jul 26:0. [Epub ahead of print ] pii: jbc.M116.7271072016 IF: 4.573.
  9. Alok Kumar Singh, Rajeev Kumar Pandey, Chandrima Shaha and Rentala Madhubala MicroRNA expression profiling of Leishmania donovani infected host cells uncovers the regulatory role of MIR30A-3p in host autophagy. Autophagy. In Press 2016
  10. Reetika Manhas, V S Gowri and Rentala Madhubala Leishmania donovani encodes a functional selenocysteinyl-tRNA synthase. J Biol Chem 291: 1203-1220. 2016
  11. Sneha Anand and Rentala Madhubala. Genetically Engineered Ascorbic acid-deficient Live Mutants of Leishmania donovani induce long lasting Protective Immunity against Visceral Leishmaniasis. Scientific Report 5:10706. doi: 10.1038/srep10706. 2015
  12. Singh AK, Pandey RK, Siqueira-Neto JL, Kwon YJ, Freitas-Junior LH, Shaha C , Madhubala R . A proteomic based approach to gain insight into reprogramming of THP-1 cells exposed to Leishmania donovani over an early temporal window. Infect Immun. 83(5):1853-68. doi: 10.1128/IAI.02833-14. Epub 2015 Feb 17. 2015
  13. Mahendra Maharjan and Rentala Madhubala Heat shock protein 70 (HSP70) expression in antimony susceptible/resistant clinical isolates of Leishmania donovan Nepal Journal of Biotechnology. 3, 1:22-28, 2015
  14. Cryptosporidium parvum has an active Hypusine Biosynthesis Pathway. Nimisha Mittal, Marie Morada, Pankaj Tripathi, V S Gowri, Swati Mandal, Alison Quirch, MyungHee Park, Nigel Yarlett, Rentala Madhubala Mol Biochem Parasitol. May 31. pii: S0166-6851(14)00071-1. doi: 10.1016/j.molbiopara.2014.05.005. [Epub ahead of print] 2014
  15. Leishmania Genome Analysis and High-throughput Immunological Screening identifies Tuzin as a Novel Vaccine Candidate against Visceral Leishmaniasis. Bhavana Sethu Lakshmi, Ruobing Wang and Rentala Madhubala. Vaccine doi: 10.1016/j.Vaccine.2014.04.088 2014
  16. Identification and functional characterization of a novel bacterial type asparagine synthetase A: A tRNA synthetase paralog from Leishmania donovani Reetika Manhas, Pankaj Tripathi, Sameena Khan, Bhavana Sethu Lakshmi, Shambhu Krishan Lal, Venkatraman Subramanian Gowri, Amit Sharma, Rentala Madhubala J Biol Chem. Apr 25; 289(17):12096-108. doi: 10.1074/jbc.M114.554642. Epub 2014 Mar 7. 2014
  17. A Quantitative Proteomics Screen to Identify Potential Drug Resistance Mechanism in α-Difluoromethylornithine (DFMO) Resistant Leishmania donovani Alok Kumar Singh, Sigrid Roberts, Buddy Ullman3 and Rentala Madhubala. Journal of Proteomics 6;102: 44-59. doi: 10.1016/j.jprot.2014.02.030. Epub 2014 Mar 12. 2014
  18. Deletion of vitamin c biosynthesis enzyme, Arabino-1, 4-Lactone Oxidase in Leishmania donovani results in increased pro-inflammatory responses from host immune cells. Reetika Manhas, Sneha Anand, Pankaj Tripathi and Rentala Madhubala. Molecular Microbiology Mar; 91(6):1227-39. doi: 10.1111/mmi.12530. Epub 2014 Feb 21. 2014
  19. Visceral and post-kala-Azar dermal leishmaniasis isolates show significant difference in their in vitro drug susceptibility pattern Jyotsna Mishra, Rentala Madhubala and Sarman Singh Parasitology Res. 112(3):1001-9. doi: 10.1007/s00436-012-3222-1. Epub 2012 Dec 18. 2013
  20. Structural insight into DFMO resistant ornithinedecarboxylase from Entamoeba histolytica: an inkling to adaptive evolution Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala and Shailly Tomar Plos One 8(1):e53397. doi: 10.1371/journal.pone.0053397. Epub 2013 Jan 11. 2013
  21. Unique posttranslational modifications in Eukaryotic translational factors and their roles in protozoan parasites viability and pathogenesis Nimisha Mittal, Gowri Subramanian, Peter Butikofer and Rentala Madhubala. Mol Biochem Parasitol; 187(1):21-31. doi: 10.1016/j.molbiopara.2012.11.001. Epub 2012 Nov 28. 2013 Featured article in malaria nexus.
  22. Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major V S Gowri, Indira Ghosh, Amit Sharma and Rentala Madhubala BMC Genomics 13: 621, 2012
  23. Quantitative proteomic profiling of the promastigotes and the intracellular amastigotes of Leishmania donovani isolates identifies novel proteins having a role in Leishmania differentiation and intracellular survival. Biyani N, Rentala Madhubala. Biochim Biophys Acta. Proteins and Proteomics 1824 (12), 1342–1350, 2012
  24. Bhavna Chawla, Ravi Ranjan Kumar, Nidhi Tyagi, Gowri Subramanian, N. Srinivasan, Myung Hee Park, Rentala Madhubala A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani Plos One, 7(3):e33138. Epub 2012 Mar 16., 2012
  25. Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala and Shailly Tomar Biochemical, mutational and In silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica PLoS Neglected Tropical Diseases, 6 (2), 1-15, 2012
  26. Unique posttranslational modifications in Eukaryotic translational factors and their roles in protozoan parasites viability and pathogenesis Nimisha Mittal, Gowri Subramanian, Peter Butikofer and Rentala Madhubala Mol Biochem Parasitol In press 2012
  27. Unusual domain architecture of aminoacyl tRNA synthetases and their paralogs from Leishmania major V S Gowri, Indira Ghosh, Amit Sharma and Rentala Madhubala BMC Genomics 13: 621, 2012
  28. Quantitative proteomic profiling of the promastigotes and the intracellular amastigotes of Leishmania donovani isolates identifies novel proteins having a role in Leishmania differentiation and intracellular survival. Biyani N, Rentala Madhubala. Biochim Biophys Acta. Proteins and Proteomics 1824 (12), 1342–1350, 2012.
  29. Bhavna Chawla, Ravi Ranjan Kumar, Nidhi Tyagi, Gowri Subramanian, N. Srinivasan, Myung Hee Park, Rentala Madhubala A unique modification of the eukaryotic initiation factor 5A shows the presence of the complete hypusine pathway in Leishmania donovani Plos One, 7(3):e33138. Epub 2012 Mar 16., 2012
  30. Preeti, Satya Tapas1, Pravindra Kumar1, Rentala Madhubala and Shailly Tomar Biochemical, mutational and In silico structural evidence for a functional dimeric form of the ornithine decarboxylase from Entamoeba histolytica PLoS Neglected Tropical Diseases, 6 (2), 1-15, 2012
  31. Bhavna Chawla, Anupam Jhingran, Aswini Panigrahi, Kenneth D. Stuart and Rentala Madhubala Paromomycin affects translation and vesicle-mediated trafficking as revealed by proteomics of paromomycin -susceptible/-resistant Leishmania donovani. Plos One, 6 (10) 1-12, 2011
  32. Neha Biyani and Rentala Madhubala Leishmania donovani encodes a functional enzyme involved in vitamin C biosynthesis: Arabino-1,4-Lactone oxidase Mol Biochem Parasitol, 180 (2), 76-85, 2011
  33. Neha Biyani, Swati Mandal, Chandan Seth, Malika Saint, K. Natarjan, Indira Ghosh and Rentala Madhubala Characterization of Leishmania Donovani Aquaporins Shows Presence of Subcellular Aquaporins Similar to Tonoplast Intrinsic Proteins of Plants. Plos One, 6 (9) e24820, 2011
  34. S. Mandal, M. A. Khomutov, A. R. Simonian, S. N. Kochetkov, and R. Madhubala Leishmania donovani: Structural Insignt in the Recognition of C_Methylated Analogues of Spermidine as Natural Polyamines Molecular Biology, 45(4), 619–623. 2011,
  35. Neha Biyani, Alok Kumar Singh, Swati Mandal, Bhavna Chawla, Rentala Madhubala Differential expression of proteins in antimony-susceptible and –resistant isolates of Leishmania donovani. Mol Biochem Parasitol, doi:10.1016/j.molbiopara.2011.06.004 179 (2) 91-99, 2011
  36. Chawla, Bhavna; Madhubala Rentala. Drug targets in Leishmania. Journal of Parasitic diseases. 34, number 1, 1-13, 2010
  37. Wang MZ, Zhu X, Srivastava A, Liu Q, Sweat JM, Pandharkar T, Stephens CE, Riccio E, Parman T, Munde M, Mandal S, Madhubala R, Tidwell RR, Wilson WD, Boykin DW, Hall JE, Kyle DE, Werbovetz KA. Novel arylimidamides for treatment of visceral leishmaniasis. Antimicrob Agents Chemother. 54(6):2507-16. Epub 2010 Apr 5. 2010
  38. Chawla B, Jhingran A, Singh S, Tyagi N, Park MH, Srinivasan N, Roberts SC, Rentala Madhubala. Identification and characterization of a novel deoxyhypusine synthase in Leishmania donovani. J Biol Chem. Jan 1; 285(1):453-63 [Epub Oct 30. 2009] 2010
  39. Mandal S, Maharjan M, Singh S, Chatterjee M, Rentala Madhubala. Assessing Aquaglyceroporin Gene Status and Expression Profile in Antimony- Susceptible and Resistant Clinical Isolates of L. donovani from India. J. Antimicrob. Chemother. 65(3):496-507. Epub 2010 Jan 12. 2010
  40. Khomutov M. A, Mandal S, Weisell J, Saxena N, Simonian A. R, Vepsalainen J, Rentala Madhubala and Kochetkov S. N. Novel convenient synthesis of biologically active esters of hydroxylamine. Amino Acids 38(2):509-17. Epub 2009 Dec 8] 2010
  41. Ankur Sharma and Rentala Madhubala Ubiquitin-Conjugation of ORFF DNA Vaccine Leads to Enhanced Cell-Mediated Immune Response and Induces Protection against Both Antimony-Susceptible and -Resistant Strains of Leishmania donovani Journal of Immunology, Dec 15;183(12):7719-31. Epub . 2009
  42. Swati C Chauhan and Rentala Madhubala Glyoxalase I gene deletion mutants of Leishmania donovani exhibit reduced methylglyoxal detoxification. pLOS One, 4(8):e6805, 2009
  43. Jhingran A, Chawla B, Saxena S, Barrett MP, Madhubala R. Paromomycin: uptake and resistance in Leishmania donovani. Mol Biochem Parasitol. 164(2):111-7. 2009
  44. Swati Mandal , Mahendra Maharjan, SudiptoGanguly, Mitali Chatterjee, Sarman Singh, Frederick S Buckner & Rentala Madhubala High-throughput screening of amastigotes of Leishmania donovani clinical isolates against drugs using a colorimetric β-lactamase assay. Indian Journal of Experimental Biology, 47, 2009
  45. Jyoti Rath, V. S. Gowri, Swati Chattopadhyay, Prasad K. Padmanabhan, N. Srinivasan and Rentala Madhubala A glutathione-specific aldose reductase of Leishmania donovani and its potential implications for methylglyoxal detoxification pathway. Gene, 429 (1-2), 1-9, 2009 http://dx.doi.org/10.1016/j.gene.2008.09.037
  46. Swati Chattopadhyaya, Prasad K. Padmanabhan and Rentala Madhubala Glyoxalase pathway of parasitic protozoa: a promising chemotherapeutic target. Current Drug Targets, 9(11):957-65 2008
  47. Mahendra Maharjan, Sushma Singh, Mitali Chatterjee, Rentala Madhubala Role of Aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani American Journal of Tropical Medicine and Hygeine, 79(1):69-75, 2008
  48. Sushma Singh, Anupam Jhingran, Ankur Sharma, Alina R. Simonian, Pasi Soininen, Jouko Vepsalainen, Alex R. Khomutov, and Rentala Madhubala Novel agmatine analogue, g-guanidinooxypropylamine (GAPA) efficiently inhibits proliferation of Leishmania donovani by depletion of intracellular polyamine levels. Biochemical and Biophysics Research Communication, 375, 168-172, 2008, doi:10.1016/j.bbrc.2008.07.143
  49. Manju Jain and Rentala Madhubala Characterization and localization of ORFF gene from the LD1 locus of Leishmania donovani Gene 416 (1-2), pp. 1-10. DOI link: http://dx.doi.org/10.1016/j.gene.2008.01.011 2008
  50. Anupam Jhingran, Prasad K. Padmanabhan, Sushma Singh, Krishanpal Anamika, Abhijeet A. Bakre, Sudha Bhattacharya, Alok Bhattacharya, Narayanaswamy Srinivasan and Rentala Madhubala Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme PLoS Neglected Tropical Diseases, 2(1), 2008
  51. Bindu Sukumaran, Manju Jain, Peter J. Myler, Kenneth. D. Stuart and Rentala Madhubala Creation of Tetracycline Regulatable Knockouts of ORFF Gene from the LD1 Locus of Leishmania donovani American Journal of Biochemistry and Biotechnology, 3 (4) 207-215, 2007
  52. Manju Jain, Vandana S. Dole, Peter J. Myler, Kenneth. D. Stuart and Rentala Madhubala Role of Biopterin Transporter (BT1) Gene on Growth and Infectivity of Leishmania American Journal of Biochemistry and Biotechnology, 3 (4) 199-206, 2007
  53. Sushma Singh, Angana Mukherjee, Alex R. Khomutov, Lo Persson, Olle Heby, Mitali Chatterjee and Rentala Madhubala Antileishmanial effect of 3-aminooxy-1-aminopropane is due to polyamine depletion. Antimicrobial Agents and Chemotherapy, 51(2):528-34, 2007
  54. Angana Mukherjee, Prasad K. Padmanabhan, Sushma Singh, Gaétan Roy, Isabelle Girard, Mitali Chatterjee, Marc Ouellette and Rentala -glutamylcysteine synthetase Madhubala Role of ABC transporter MRPA, and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani Journal of Antimicrobial Agents and Chemotherapeutics 59(2):204-11, 2007.
  55. Poonam Tewary, Shailendra Saxena and Rentala Madhubala. Co-administration of IL-12 DNA with rORFF antigen confers long-term protective immunity against experimental visceral leishmaniaisis. Vaccine, 24(13):2409-16., 2006
  56. Poonam Tewary, Kumari Veena, Thomas J Pucadyil, Amitabha Chattopadhyay and Rentala Madhubala. The Sterol-Binding Antibiotic Nystatin Inhibits Entry of Non-opsonized Leishmania donovani in to Macrophages. Biochemical and Biophysics Research Communication, 339(2):661-6., 2006
  57. Prasad K. Padmanabhan, Angana Mukherjee and Rentala Madhubala. Characterization of gene encoding glyoxalase II from Leishmania donovani: A potential anti-parasite drug. Biochemical Journal, 393(Pt 1):227-34., 2006
  58. Angana Mukherjee, Prasad K. Padmanabhan, Mayurbhai H. Sahani, Michael Peter Barrett and Rentala Madhubala Roles for mitochondria in pentamidine susceptibility and resistance in Leishmania donovani. Molecular and Biochemical Parasitology, 145(1):1-10, 2006
  59. Prasad K. Padmanabhan, Angana Mukherjee, Sushma Singh, Swati Chattopadhyaya, Peter J Myler, Narayanaswamy Srinivasan and Rentala Madhubala. Glyoxalase I from Leishmania donovani: A potential target for anti-parasite drug. Biochemical and Biophysics Research Communication, 337(4):1237-48. 2005
  60. Poonam Tewary, Manju Jain, Mayurbhai Sahani, Shailendra Saxena and Rentala Madhubala A Heterologous Prime Boost Vaccine regimen using ORFF DNA and Recombinant ORFF Protein confers Protective Immunity against Experimental Visceral Leishmaniasis in Murine Mouse Model. Journal of Infectious Diseases, 191(12), 2130-2137, 2005
  61. Sridevi Balaraman, Vandana Km. Singh, Poonam Tewary and Rentala Madhubala Leishmania Lipophosphoglycan Activates the Transcription Factor Activating Protein 1 in J774A.1 Macrophages through the Extracellular Signal-Related Kinase (ERK) and p38 Mitogen-Activated Protein Kinase. Molecular and Biochemical Parasitology, 139, 117-127, 2005
  62. Vandana Km. Singh Sridevi Balaraman, Poonam Tewary and Rentala Madhubala Leishmania donovani Activates Nuclear Transcription Factor- in Macrophages Through Reactive Oxygen intermediates Biochemical and Biophysics Research Communication, 322, 1086-1095, 2004
  63. Sridevi Balaraman, Poonam Tewary, Vandana Km. Singh, and Rentala Madhubala Leishmania donovani Induces Interferon Regulatory Factor (IRF) in Murine Macrophages: A Host Defense Response Biochemical and Biophysics Research Communication, 317(2): 639-47, 2004
  64. Poonam Tewary, Jayesh Pandyan, Bindu Sukumaran and Rentala Madhubala Vaccination with Leishmania soluble antigen and immunostimulatory oligodeoxynucleotides inducs specific immunity and protection against Leishmania donovani infection. FEMS Immunology and Medical Microbiology, 42 (2): 241-248, 2004. Corrigendum to: ‘Vaccination with Leishmania soluble antigen and immunostimulatory oligodeoxynucleotides induces specific immunity and protection against Leishmania donovani infection’ FEMS Immunology and Medical Microbiology, 43, 103, 2005
  65. Thomas J. Pucadyil, Poonam Tewary, Rentala Madhubala, and Amitabha Chattopadhyay Cholesterol is required for Leishmania donovani infection: Implications in leishmaniasis. Molecular and Biochemical Parasitology, 133, 145-152, 2004.
  66. Poonam Tewary, Bindu Sukumaran, Shailendra Saxena and Rentala Madhubala Immunostimulatory Oligo-deoxynucleotides are potent enhancers of specific immunity in mice immunized with recombinant ORFF leishmanial antigen Vaccine 22/23-24, 3053-3060, 2004
  67. Bindu Sukumaran, Poonam Tewary, Shailendra Saxena and Rentala Madhubala Vaccination with DNA encoding ORFF antigen confers protective immunity in mice infected with Leishmania donovani Vaccine 21, 1292-1299, 2003
  68. Vandana S. Dole., Myler, P.J., Stuart, K. D and Rentala Madhubala Expression of Biopterin transporter protein in Leishmania FEMS Microbiol. Letts. 208 (1) 89-91, 2002.
  69. Kapoor. P., Raj. V.S., Saxena, S., Sridevi Balaraman., and Rentala Madhubala Effect of Leishmania donovani lipophosphoglycan on signal transduction in macrophages. Journal of Parasitology 87 (5) Oct., 1071-1076, 2001.
  70. Peter. J. Myler, Stephen M. Beverley, Angela K. Cruz, Alasdair C. Ivens, Paul D. McDonagh, Rentala Madhubala, Santiago Martinez-Calvillo, Jeronimo C. Ruiz, AlkaSaxena, Ellen Sisk, Susan M. Sunkin, Elizabeth Worthey, Shaofeng Yan, and Kenneth D. Stuart The Leishmania genome project: new insights into gene organization and function. Medical Microbiology and Immunology 190, 9-12, 2001.
  71. Chiurello, M.A., Sachdeva, M., Dole, V.S., Yepes, Y., Milani, E., Vazquez, L., Rojas, A., Cristane, G., Guevara, P., Anez, N., Madhubala, R., Ramirez, J.L. Detection of Leishmania causing visceral leishmaniasis in the old and new world by a polymerase chain reaction assay based on telomeric sequences. American Journal of Tropical Medicine and Hygiene. 65, (5), 573-582, 2001.
  72. Vandana S. Dole., V.Samuel Raj., Madhubala, R., Myler, P.J and Stuart, K. D. Immunization with recombinant LD1 antigens protects against experimental leishmaniasis. Vaccine., 19(4-5), 423-430, 2001.
  73. Myler, P.J., Ellen Sisk, Paul D McDonagh, Santiago Martinez-Calvillo, Achim Schnaufer, Susan M Sunkin, Shaofeng, Yan, Rentala Madhubala, Alsadair Ivens and Stuart. K.D. Genomic organization and gene function in Leishmania. Biochemical Society Transactions. Oct 1, 28(5), 527-531, 2000.
  74. Sidhu A.B. and Madhubala, R. Plasmodium falciparum: Detection and strain identification by polymerase chain reaction South East Asian Journal of Tropical Medicine and International Health. 31, (2), 213-218, 2000.
  75. Kapoor., P. Sachdeva., Monica and Madhubala., Rentala. Inhibition of glutathione synthesis a chemotherapeutic strategy for leishmaniasis. Tropical Medicine and International Health. 5, (6), 438-442, 2000.
  76. Sylke Muller, A. A.Dadara, K. Luersen, Carsten Wrenger, Robin Das Gupta, Rentala Madhubala and R.D.Walter. In the human malaria parasite Plasmodium falciparum polyamines are synthesized by a bifunctional ornithine decarboxylase-S-adenosylmethionine decarboxylase. Journal of Biological Chemistry, 275, 8097-8102, 2000.
  77. Das, B., Monica Vig., Kamal, K. Khurana and Madhubala, R. Isolation and characterization of human adenocarcinoma cells made resistant to alpha difluoromethyl ornithine. Cancer Investigation, 18, 115-122, 2000.
  78. Ghosh, A., Madhubala, R., Myler, P.J., and Stuart. K.D. Leishmania donovani: Characterization and expression of ORFF, a gene amplified from the LD1 locus. Experimental Parasitology, 93, 225-230. 1999.
  79. Lemely,C., Shaofeng Yan, Dole, V., Madhubala, R., Cunningham, M.W., Beverley, S.M., Myler, P.J., and Stuart, K.D. The Leishmania LD1 ORFG encodes a biopterin transporter (BT1). Molecular and Biochemical Parasitology, 104, 93-105, 1999.
  80. Kapoor, P., and Madhubala,R., Effect of a microtubule stabalizing agent taxol on Leishmanial protozoan parasites in vitro. FEMS Microbiol. Letts. 176, 429-435, 1999.
  81. Kapoor.P., Ghosh., A and Madhubala,R., Isolation of a taxol resistant L.donovani promastigote mutant that exhibits a multidrug resistant phenotype. FEMS Microbiol. Letts. 176, 437-441, 1999.
  82. Das,B., Khurana, K. K and Madhubala ,R. Regulation of polyamine biosynthetic pathway in MCF-7 human breast cancer cell line by selenium Indian Journal of Pharmaceutical Science. 61, 213-218, 1999.
  83. Samuel,R.V., Ghosh,A., Dole,V., Madhubala,R. Myler,P.J. and Stuart,K. Serodiagnosis of Indian visceral leishmaniasis by a recombinant antigen from the open reading frame F from theLD1 loci of Leishmania donovani. American Journal of Tropical Medicine and Hygiene, 61, 482-487, 1999.
  84. Hashim, S., Banerjee, S., Madhubala, R., and Rao,A.R. Chemoprevention of DMBA- induced transplacental and translactational carcinogenesis in mice by oil from mustard seeds (Brassica sp). Cancer Letters, 134, 217-226, 1998.
  85. Das,B., Ramesh Rao,A., and Madhubala, R. Difluorometyl ornithine antagonises taxol cytotoxicity in MCF-7 human breast cancer cells. Oncology Research, 9, 565-572, 1997.
  86. Das, B., Gupta, R and Madhubala, R. Combined action of inhibitors of S-adenosylmethionine decarboxylase with known antimalarial chloroquine on Plasmodium falciparum. Journal of Eukaryotic Microbiology, 44, 12-17, 1997.
  87. Mukhopadhyay, R., Kapoor, P. and Madhubala, R. Antileishmanial activity of a potent S-adenosylmethionine decarboxylase inhibitor CGP 40215A. Pharmacological Research, 33, 67-70, 1996a.
  88. Mukhopadhayay, R. Kapoor, P., Madhubala, R. Characterization of difluoromethyl resistant Leishmania donovani and it's susceptibility to other inhibitors of polyamine biosynthetic path way. Pharmacological Research, 34, 43-46, 1996b.
  89. Lodes, J., Merlin, G., Devos, T., Ghosh, A., Madhubala, R., Myler, P.J. and Stuart, K. Increased expression of LD1 genes using RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus. Molecular and Cellular Biology, 15, 6845-6853, 1995.
  90. Gupta, R., Dhanjal, V. and Madhubala, R. Stage dependent effect of P. falciparum in vitro by chloroquine and inhibitors of polyamine biosynthetic pathway. Journal of Parasitic Diseases, 19, 49-54, 1995.
  91. Das, B., Gupta, R. and Madhubala, R. Combined action of inhibitors of polyamine biosynthetic pathway with a known antimalarial drug chloroquine on Plasmodium falciparum. Pharmacological Research, 31, 3-4, 189-193, 1995.
  92. Mukhopadhyay, R. and Madhubala, R. Antileishmanial activity of Berenil and Methylglyoxal bis (guanylhydrazone) and its correlation with S-adenosylmethionine decarboxylase and polyamines. International Journal of Biochemistry and Cell Biology, 27, 55-59, 1995a.
  93. Mukhopadhyay, R. and Madhubala, R. Leishmania donovani: Cellular control of ornithine decarboxylase in promastigotes. International Journal of Biochemistry Cell Biology, 27, 947-956, 1995b.
  94. Mukhopadhyay, R. and Madhubala, R. Effect of bis (benzyl) polyamine analogs on Leishmania donovani promastigotes. Experimental Parasitology, 81, 39-46 1995.
  95. Hashim, S., Aboobaker, V.S., Madhubala, R., Bhattacharya, A.K. and Rao, A.R. Modulatory effects of essential oils from spcies on the formation of DNA adduct by Afflatoxin B1 in vitro. Nutrition and Cancer, 21, 169-175, 1994.
  96. Mukhopadhyay, R. and Madhubala, R. Effect of antioxidants on the growth and polyamine levels of Leishmania donovani. Biochemical Pharmacology, 47, 611-615, 1994a.
  97. Mukhopadhyay, R. and Madhubala, R. Antileishmanial activity and modification of hepatic xenobiotic metabolizing enzymes in golden hamster by 2(3)-Tert-Butyl-1-hydryanisole following infection with Leishmania donovani. Biochemical Pharmacology, 47, 253-256, 1994b.
  98. Mukhopadhyay, R. and Madhubala, R. Effect of bis (benzyl) polyamine analogs and DL-(-difluromethyl ornithine on parasite suppression and cellular polamine levels in golden hamster during Leishmania donovani infection. Pharmacological Research, 28, 359-365, 1993.
  99. Madhubala, R. and Pegg, A.E. Inhibition of ornithine decarboxylase and S(adenosylmethionine decarboxylase synthesis by antisense oligodeoxy nucleotides. Molecular and Cellular Biochemistry, 118, 191-195, 1992.
  100. Porter, C.W., Pegg, A.E., Gains, B., Madhubala, R. and Bergeron, R.J. Combined regulation of ornithine and S-adenosylmethionine decarboxylase by spermine and spermine analogue N1 N12-bis (ethyl) spermine. Biochemical Journal, 266, 207-211, 1990.
  101. Pajunen, A., Crozat, A., Janne, O.A., lhalainen, R., Latinen, P. H., Stanley, B., Madhubala, R. and Pegg, A. E. Structure and regulation of mammalian S-adenosylmeyhionine decarboxylase. Journal of Biological Chemistry, 263, 17040-17049, 1988.
  102. Madhubala, R. and Secrist, J.A. and Pegg, A.E. Effect of inhibitors of S-adenosylmethionine decarboxylase on the contents of ornithine decarboxylase and S-adenosylmethionine decarboxylase in L1210 cells. Biochemical Journal, 254, 45-50, 1988.
  103. Pegg, A.E. Madhubala, R. and Secrist, J.A. Properties of L1210 cells resistant to difluoromethyl ornithine. Cancer Research, 48, 2678-2682, 1988.
  104. Pegg, A.E., Madhubala, R. Kameji, T. and Bergernon, R.J. Control of ornithine decarboxylase activity in difluoromethylornithine resistant L1210 cells by polyamines and synthetic analogs. Journal of Biological Chemistry, 263: 11008-11014, 1988.
  105. Pegg. A.E., Kameji, T., Shrihata, A., Stanley, B., Madhubala, R. and Pajunen, A. Regulation of mammalian S-adenosylmethionine decarboxylase. Advances in Enzymology, 27: 43-46, 1988.
  106. Reddy, B.V. and Madhubala, R., and Reddy, P.R.K. Desensitization of immature rat testicular ornithine decarboxylase by arginovasopressin. Biochemistry International, 15, 545-552, 1987.
  107. Madhubala, R. Shubada, S. and Steinberger, A and Tsai, Y.H. Inhibition of ornithine decarboxylase activity by follicle stimulating hormone in primary culture of rat sertoli cells. Journal of Andrology, 8: 383-387, 1987.
  108. Reddy, B.V. and Madhubala, R. and Reddy, P.R.K. Stimulation of testicular ornithine decarboxylase by arginovasopressin. Biochemistry International, 13: 109-114, 1986.
  109. Madhubala, R. and Reddy, P.R.K. Effect of difluoromethylornithine on the testis of rat. Journal of Reproductive Biology and Comparative Endocrinology, 5: 7-12, 1985.
  110. Madhubala, R. and Reddy, P.R.K. Desensitization of testicular ornithine decarboxylase to gonadotropic releasing hormone and gonadotropic hormones. Biochemistry International, 11: 225-232, 1985.
  111. Madhubala, R. and Reddy, P.R.K. Desensitization of testicular ornithine decarboxylase to prostaglandin E2. Biochemistry International, 8: 437-444, 1984
  112. Madhubala, R. and Reddy, P.R.K. Desensitization of ornithine decarboxylase activity to nor ephinephrine in the tests of rat. Life Sciences, 34: 1041-1048, 1983.
  113. Madhubala, R. and Reddy, P.R.K. Inhibition of epinephrine and gonadotropic hormone induced ornithine decarboxylase activity by phenoxybenzamine in the testis of immature rat. FEBS Letters, 152:199-201,1983.
  114. Madhubala, R. and Reddy, P.R.K. Stimulation of ornithine decarboxylase activity by leutenizing hormone releasing hormone in the testis of Immature rat. Biochemical and Biophysical Research Communications, 109: 269-274, 1982.
  115. Madhubala, R. and Reddy, P.R.K. Effect of catecholamines on ornithine decarboxylase activity in the testis of immature rat. Biochemical and Biophysical Research Communications, 102: 1096-1103, 1981.
  116. Madhubala, R. and Reddy, P.R.K. Stimulation of ornithine decarboxylase activity by prostaglandins in the isolated cells of immature rat testis. FEBS Letters, 122: 197-198, 1980.
  117. Madhubala, R. and Reddy, P.R.K. Effect of prostaglandins on ornithine decarboxylase activity in testis of immature rat. Prostaglandins, 20: 503-513, 1980.

REVIEWS

  1. Olle Heby, Lo Persson, Madhubala Rentala Review Article Targeting the polyamine biosynthetic enzymes: A promising approach to therapy of African sleeping sickness, Chagas’ disease, and leishmaniasis Amino acids, 33: 359-366, 2007.
  2. Bindu Sukumaran and Rentala Madhubala Leishmaniasis: Current status of vaccine development Current Molecular Medicine 4, 667-679, 2004.
  3. Madhubala Rentala, Saxena S, Myler P. J., Stuart, K.D Functional genomics in Leishmania Proc. Indian Natl. Sci Acad. (PINSA) B68, 5, 379-388, 2002.
  4. Bindu Sukumaran and Rentala Madhubala LD1: An amplified DNA of Leishmania Journal of Parasitic Disease 27, 13-20, 2003

ABSTRACTS

  1. Madhubala, R., Secrist, J.A. III and Pegg, A.E. Properties of L1210 cells resistant to difluoromethyl ornithine (DFMO). Federation Proceedings, 46: 2254, 1987.
  2. Madhubala, R. Steinberger, A. and Tsai, Y.H. Inhibition of ornithine decarboxylase activity by follicle stimulating hormone in primary culture of rat Sertoli cells. Journal of Cell Biology, 103, 485a, 1812A, 1986.
  3. Reddy, P.R.K. and Madhubala, R. Regulation of ornithine decarboxylase by prostaglandins in the testis of rat. Israel Journal of Medical Sciences, 17: 727, 1981.

PROCEEDINGS/ CHAPTERS IN BOOKS

  1. Anupam Jhingran, Mitali Chatterjee, Rentala Madhubala Epidemiology and Diagnosis, Chapter 1. In: Leishmania after the genome, Ed. Peter J. Myler and Nicolas Fasel, Horizon Scientific Press/Caister Academic, April, 2008.
  2. Rentala Madhubala, Poonam Tewary, Vandana Km. Singh, Kalicharan Patra. Experiences with a Leishmania Vaccine, In: Trends and Research in Leishmaniasis with particular reference to Kala Azar, Ed. Raghunath D. and Nayak, R, Pg.327-341, Tata Mcgraw-Hill, 2005.
  3. Madhubala, R. Thin layer chromatographic methods for assaying polyamines. In; Polyamine Protocols, Methods in Molecular Biology. Ed. DML Morgan, publisher Humana Press Inc., NJ, USA. 79,131-136, 1998.
  4. Madhubala Rentala, Third generation vaccines, In: Kala-azar, Proceedings of the fifth Round table conference, Series No. 5, Ranbaxy Science Foundation, Ed Dr. Sushma Gupta and Dr. O. P. Sood, 1999.
  5. Kapoor, P., Mukhopadhyay, R. and Madhubala, R. Polyamine biosynthetic pathway: A potential target for chemotherapy in Leishmania donovani infections. In: Indian Kala Azar, Ed. Dr. Shyam Sundar, Varanasi. 1997.
  6. Reddy, P.R.K. Madhubala, R. and Reddy, V.V. Desensitization of Leydig cell receptor by various hormones. In: Current Trends in Life Sciences, XIII Biomembrane structure biogenesis and transport, 91-97. Today and Tomorrow Printers and Publishers, New Delhi, 1985.
  7. Reddy, P.R.K. and Madhubala, R. and Rukmini, V. Hormonal regulation of some regulatory enzymes in the testis of rat: Proceedings of the symposium on cellular control mechanisms organized by basic science committee II, Board of Research in nuclear sciences, Department of Atomic energy, Govt. of India, 1982

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