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Swati Tiwari

Swati Tiwari

Swati Tiwari
Swati Tiwari
Assistant Professor
Centre/School/Special Centre
School of Biotechnology
Room No
128
Off. Phone
011-26738755
Email
swati_tiwari@mail.jnu.ac.in
Personal files
Faculty webpage_updated_2023_0.pdf
Qualifications

Ph. D., School of Life Sciences, JNU

Areas of Interest/Specialization

In my laboratory, we use mammalian cells and protozoan parasite as model systems to address questions in the broad area of 'Molecular Cell biology in Health and Disease'. We have special interest in inter-disciplinary studies at the interface between molecular and cell biology to understand the role of ubiquitin-proteasome system in the control of cellular functions. The current interests include

(a) Ubiquitin proteasome pathway in cell cycle regulation

(b) protein quality control mechanisms and phagocytosis

(c) host-pathogen interactions

(d) Ubiquitin pathway mediated regulation of the development changes in E. histolytica

(e) Screening of selective inhibitors against the 26S proteasomes of E. histolytica

Experience

2008-Present Assistant Professor, School of Biotechnology, Jawaharlal Nehru University, New Delhi
2005-2008 Lecturer, School of Biotechnology, GGSIP University, Delhi
2004-2005 School of Environmental Sciences, Jawaharlal Nehru University, New Delhi on Department of Science and Technology funded project
2001-2002 Research Associate, Regulation of Protein Function Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, U.S.A.
1996-2000 Visiting Fellow, Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, U.S.A. 

Awards & Honours

2016 Visitors Award for Research constituted by the President of India. Awarded as part of the JNU Molecular Parasitology Group for Best Research by the Honorable President, Shri Pranab Mukherjee at Rashtrapati Bhawan

International Fellowships

1996 - 2000 Fogarty International Visiting Fellowship
1991 - 1996 Senior Research Fellowship, Council for Scientific and Industrial Research, Government of India
1988 - 1990 Junior Research Fellowship, Council for Scientific and Industrial Research, Government of India 

Research grants

Research grants have been received from all national granting agencies. Currently running grants are funded by STARS/MHRD (in collaboration with Dr. Sunando Datta, IISER Bhopal), DST funded multi-investigator grant "National Centre for screening natural products for parasitic diseases, and ICMR. Past grants include funding from DBT, DRDO and DST. Funding was also received from DBT-BUILDER, DST-Centre of Excellence in molecular parasitology, DST-PURSE and UPE-II grant.

Best Peer Reviewed Publications
  1. Lalnunthangi, A.,  Dakpa, G., Tiwari, S. (2022) Multifunctional role of the ubiquitin proteasome pathway in phagocytosis. Progress in Molecular Biology and Translational Science (PMBTS): Receptor Endocytosis And Signalling In Health And Disease Volume 194, Chapter 27, pp. 179-217, Elsevier, Eds. Singh, V., Babu, I.
  2. Sharma, R., Tiwari, S., Dixit, A. (2021) Covaxin: An overview of its immunogenicity and safety trials in India. Bioinformation 17(10): 840-84
  3. Ramanujan, A., Bansal, S., Guha, M., Pande, N. T., Tiwari S. (2021) LxCxE motif of the APC/C coactivator subunit FZR1 is critical for interaction with the retinoblastoma protein. Exp Cell Res. 404:112632 doi: 10.1016/j.yexcr.2021.112632
  4. Bansal, S., Tiwari, S. (2019) Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome Cell Div. 14: 14/ doi: 10.1186/s13008-019-0057-5
  5. Kumari, R., Gupta, P. and Tiwari, S. (2018) Ubc7/Ube2g2 ortholog in Entamoeba histolytica: connection with the plasma membrane and phagocytosis. Parasitol. Res. 117, 1599-1611/ doi 10.1007/s00436-018-5842-6
  6. Ramanujan, A. and Tiwari, S. (2016) APC/C and Retinoblastoma interaction: Cross-talk of Retinoblastoma protein with the Ubiquitin Proteasome Pathway. Biosci. Rep. 36/ art:e00377 / doi 10.1042/BSR20160152
  7. Arya, S., Sharma, G., Gupta, P. and Tiwari, S. (2012) In silico analysis of ubiquitin/ubiquitin-like modifiers and their conjugating enzymes in Entamoeba species. Parasitol. Res. 111: 37-51.
  8. Webster, J. M., Tiwari, S., Weissman, A. M. and Wojcikiewicz, R. J. H. (2003) Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mamalian Ubc7, a component of the Endoplasmic Reticulum-Associated Degradation pathway, and is inhibited by chelation of intracellular Zn2+. J. Biol. Chem. 278: 38238-38246.
  9. Magnifico, A., Ettenberg, S., Yang, C., Mariano, J., Tiwari, S., Fang, F., Lipkowitz, S., and Weissman, A. M. (2003) HECT E3s target Cbl proteins for proteasomal degradation: implications for tyrosine kinase-mediated regulation. J. Biol. Chem. 278: 43169-43177.
  10. Fang, S., Ferrone, M., Yang, C., Tiwari, S., and Weissman, A. M. (2001) The tumor autocrine motility factor receptor, GP78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 98: 14422-14427.
  11. Tiwari, S. and Weissman, A. M. (2001) Endoplasmic Reticulum Associated Degradation (ERAD) of T-cell receptor subunits: Involvement of ER-associated Ubiquitin Conjugating Enzymes (E2s). J. Biol. Chem. 19: 16193-16200. 
Recent Peer Reviewed Journals/Books

Book Chapter

  1. Lalnunthangi, A.,  Dakpa, G., Tiwari, S. (2022) Multifunctional role of the ubiquitin proteasome pathway in phagocytosis. Progress in Molecular Biology and Translational Science (PMBTS): Receptor Endocytosis And Signalling In Health And Disease Volume 194, Chapter 27, pp. 179-217, Elsevier, Eds. Singh, V., Babu, I.

 

Miscellaneous Publications

  1. Kumar, D., Tiwari, S., Naithani, S. Govindjee, G. (2022) Remembering Professor Krishna K. Tewari (1937–2017): A Pioneer in Plant Molecular Biology. Current Plant Biol., 29: 100240
  2. Tiwari, S. (2015) Book review: Photosynthesis: Basics to applications. Current Science, 109: 2313
  3. Tiwari, S. (2015) Book review: Photobiology: The Science of Light and Life. Current Science, 108: 2106
  4. Tiwari, S., Tripathy B. C., Jajoo A., Das, A. B., Murata, N., Sane, P. V., Govindjee (2014) Prasanna K. Mohanty (1934–2013): a great photosynthetiker and a wonderful human being who touched the hearts of many. Photosynth. Res., 122: 235-260
  5. Prakash, J. S. S. and Tiwari S. (2013) Prasanna Mohanty (1934–2013): a pioneer and a loving teacher. Physiol Mol Biol Plants 19: 301-305

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.