Ph.D. (2006) from Central Drug Research Institute (CDRI), Lucknow, India
M.Sc. (2001) from University of Lucknow, Lucknow, India
B.Sc. (1998) from University of Lucknow, Lucknow, India
Glyco-Chemistry, Synthetic Organic Chemistry, Carbohydrates and Proteins, Medicinal Chemistry and Chemical Biology
Professor, School of Physical Sciences, Jawaharlal Nehru University (JNU), New Delhi (2020- present).
Associate Professor, Department of Chemistry, Banaras Hindu University (BHU), Varanasi (2018-2020).
Assistant Professor, Department of Chemistry, Shiv Nadar University (SNU), Greater Noida (2012-2018).
Senior BBSRC Postdoctoral Fellow at University of Oxford, United Kingdom (2008 - 2012) with Prof. Ben Davis.
BK21 Postdoctoral Fellow at Seoul National University, S. Korea (2007 - 2008) with Prof. Seung Bum Park.
Research Associate at Indian Institute of Technology Kanpur (IITK), India (2006-2007) with Prof. Y.D. Vankar
- BBSRC UK postdoctoral fellowship, University of Oxford, Oxford, United Kingdom.
- Brain Korea-21 postdoctoral fellowship, Seoul National University, Seoul, South Korea.
- Worked as Academic Visitor at Department of Chemistry, IIT Kanpur during 15th December 2016 to 15th January 2017.
- Visiting Fellowship as Vising Scientist at ICMS, JNCASR Bangalore during 23rd May to 10th July 2019.
· Collaborating on neurotoxin work with Dr. Yinghua Ma from Weill Cornell Medical College, Cornell University, USA.
· Colloborating on SPARC proposal with Dr. Goncalo Bernardes from Department of Chemistry, University of Cambridge, UK.
· Collaborating on glycosidase inhibitor project with Dr. Atsushi Kato University of Toyama, Japan
1. Synthesis of Chirally Enriched Pyrazolylpyrimidinone based Glycohybrids via Annulation of Glycals with 2-hydrazineylpyrimidin-4(3H)-ones. Ghanshyam Tiwari, Vinay Kumar Mishra, Ashish Khanna, Rajdeep Tyagi and Ram Sagar*
J. Org. Chem. 2024, 89, 5000–5009. [IF 3.60].
2. Base-Induced Annulation of Glycal-Derived α-iodopyranone with 2-Aminopyrimidinones: Access to Chiral Imidazopyrimidinones. Vinay Kumar Mishra, Ghanshyam Tiwari, Ashish Khanna, Yogesh Yadav and Ram Sagar*
Eur. J. Org. Chem. 2024, 27, e202301301. [IF 3.26].
3. Recent Efforts in the Development of Glycoconjugate Vaccine and available treatment for Tuberculosis. Sajida Banoo, Yogesh Yadav, Rajdeep Tyagi, Arunava Manna, Ram Sagar*
Bioorg. Chem. 2024, 150, 107610. [IF 4.50].
4. Electro-organic synthesis of isatins and hydrazones through C–N cross-coupling and C(sp2)–H/C(sp3)–H functionalization. Neetu Verma, Rajdeep Tyagi, Ashish Khanna, Manisha Malviya and Ram Sagar*
Org. Biomol. Chem., 2023, 21, 6707-6714. [IF 3.89].
5. Conformationally locked sugar derivatives and analogues as potential neuraminidase inhibitors. Yogesh Yadav, Rajdeep Tyagi, Ramesh Kumar, Ram Sagar*
Eur. J. Med. Chem. 2023, 255, 115410. [IF 6.00].
6. Triazole linked N-acetylglucosamine based gelators for crude oil separation and dye removal. Chintam Narayana, Priti Kumari, and Ram Sagar*
Langmuir 2019, 35, 16803-16812. [IF 3.68]
7. Regioselective Synthesis of Chirally Enriched Tetrahydrocarbazolones and Tetrahydrocarbazoles. Chintam Narayana, Priti Kumari, and Ram Sagar*
Org. Lett. 2018, 20, 4240–4244. [IF 6.58]
8. Stereoselective synthesis of natural product inspired carbohydrate fused pyrano[3,2-c]quinolones as antiproliferative agents. Priti Kumari, Chintam Narayana, Shraddha Dubey, Ashish Gupta and Ram Sagar*
Org. Biomol. Chem. 2018, 16, 2049-2059. [IF 3.56]
9. Chemical intervention in plant sugar signalling increases yield and resilience. Cara A. Griffiths,* Ram Sagar,* Yiqun Geng,* Lucia F. Primavesi, Mitul K. Patel, Melissa K. Passarelli, Ian S. Gilmore, Rory T. Steven, Josephine Bunch, Matthew J. Paul, and Benjamin G. Davis
Nature, 2016, 540, 574-578. [IF 38.14] (* These are joint first authors)
10. Glycal Derived δ-Hydroxy α,β-unsaturated aldehydes (Perlin aldehydes): A Versatile Building Block in Organic Synthesis. L. V. R. Reddy, Vikas Kumar, Ram Sagar and Arun K. Shaw
Chem. Rev. 2013, 113, 3605-3631. [IF 40.12]
11. Conformational Effects in Sugar Ions: Spectroscopic Investigations in the Gas Phase and in Solution. Ram Sagar, Svemir Rudic, et al John P Simons and Benjamin G. Davis.
Chem Sci. 2012, 3, 2307-2313. [IF 9.14]
12. Diastereoselective Synthesis of Polycyclic Acetal-Fused Pyrano[3,2-c]pyran-5(2H)-one derivatives. Ram Sagar , Jongmin Park, Minseob Koh and Seung Bum Park.
J. Org. Chem. 2009, 74, 2171-2174. [IF 4.84]
13. Facile and efficient synthesis of carbohybrids as stereodivergent drug like small molecules. Ram Sagar and Seung Bum Park.
J. Org. Chem. 2008, 73, 3270-3273. [IF 4.84]
14. C-3 Alkyl/Arylalkyl-2,3-dideoxy Hex-2-enopyranosides as Antitubercular Agents: Synthesis, Biological Evaluation, and QSAR Study. Mohammad Saquib, Manish K. Gupta, Ram Sagar, Yenamandra S. Prabhakar, Arun K. Shaw et al.
J. Med. Chem. 2007, 50, 2942-2950. [IF 6.25]
Journals:
15. Efficient Synthesis of Indole-chalcones based Glycohybrids and their Anti-cancer activity. Rajdeep Tyagi, Kanchan Yadav, Ashish Khanna, Sunil K. Mishra and Ram Sagar*
Bioorg. Med. Chem. 2024, 109, 117778. [IF 3.30].
16. Efficient synthesis of chirally enriched 1H-imidazo [1,2-b] pyrazole and 4Himidazo[1,2-b][1,2,4]triazole based bioactive Glycohybrids. Vinay Kumar Mishra, Ghanshyam Tiwari, Ashish Khanna, Rajdeep Tyagi, Ram Sagar *
Synthesis, 2024, 56, 1017-1025. [IF 2.70].
17. An efficient synthesis of natural product-inspired naphthoquinone fused glycohybrids and their in-silico docking studies. Ashish Khanna, Ghanshyam Tiwari, Vinay Kumar Mishra, Kavita Singh, Ram Sagar*
Synthesis, 2024, 56, 989-998. [IF 2.70].
18. Recent developments on the synthesis of biologically active glycohybrids. Vinay Kumar Mishra, Ashish Khanna, Ghanshyam Tiwari, Rajdeep Tyagi and Ram Sagar*
Bioorg. Chem. 2024, 145, 107172. [IF 4.50].
19. Copper-catalyzed synthesis of pyrazolo[1,5-a]pyrimidine based triazole-linked glycohybrids: mechanistic insights and bio-applications. Ghanshyam Tiwari, Ashish Khanna, Rajdeep Tyagi, Vinay Kumar Mishra, Chintam Narayana and Ram Sagar*
Sci. Rep. 2024, 14, 529. [IF 4.25].
20. Reinvestigation of SnCl4 catalyzed efficient synthesis of 2,3-unsaturated glycopyranosides. Yogesh Yadav, Rajdeep Tyagi, Kanchan Yadav, Ghanshyam Tiwari and Ram Sagar*
Carbohydr. Res. 2023, 534, 108989. [IF 2.50].
21. Metal free synthesis of 2,3-dideoxy-α, β-unsaturated carbohydrate enals (Perlin aldehydes). Kavita Singh, Sourav Sagar Behera, Rajdeep Tyagi, Ghanshyam Tiwari, Ram Sagar*
Carbohydr. Res. 2023, 531, 108890. [IF 2.50].
Books:
1. Conformationally restricted glycoside derivatives as mechanistic probes and/or inhibitors of sugar processing enzymes and receptors (Chapter 20). Carine Maaliki, Charles Gauthier, Olivier Massinon, Ram Sagar, Stéphane P. Vincent and Yves Blériot,
Carbohydrate Chemistry 2014, 40, pp 418-444. (ISBN: 978-1-84973-965-8)
Publisher: Royal Society of Chemistry (RSC), London, United Kingdom.
2. Glycohybrid Molecules in Medicinal Chemistry: Present Status and Future Prospective (Chapter 11). Priti Kumari, Ghanshyam Tiwari, Chintam Narayana and Ram Sagar*
Carbohydrates in Drug Discovery and Development 2020, pp 1-35 (ISBN: 978-0-12816-675-8).
Publisher: Elsevier Publication, United Kingdom
3. Recent advances in synthesis of diverse glycopeptides and glycohybrids (Chapter 12). Rajdeep Tyagi, Kavita Singh, Vinay Kumar Mishra and Ram Sagar*
Synthetic Strategies in Carbohydrate Chemistry 2024, pp 523-609 (ISBN: 978-0-323-91729-2).
Publisher: Elsevier Publication, United Kingdom
1. Glycoside based anti-toxin for Epsilon intoxification and preparation method thereof. Chintam Narayana, Abhishek Shivappagowdar, Ram Sagar, Soumya Pati, Shailja Singh Indian Patent 2018 (No. 201811034958).
2. Modification of trehalose-6-phosphate level in plants. Ram Sagar, Lucia F. Primevessi, Matthew J. Paul and Benjamin G. Davis. US Patent 2013 (US9023763B2). (Granted 5 May 2015)
3. Modification of trehalose-6-phosphate level in plants. Ram Sagar, Lucia F. Primevessi, Matthew J. Paul and Benjamin G. Davis. PCT Patent 2012 (PCT/GB12/050891).
4. Metabolic Intervention in plant T6P Metabolism. Ram Sagar, Lucia F. Primevessi, Matthew J. Paul, Mitul K. Patel, Conor S. Barry and Benjamin G. Davis. UK Patent 2011 (No. 01107031.5) 26.04.2011
5. C-3-alkyl and arylalkyl substituted 2,3-dideoxy glucopyranosides as potential anti-tubercular agents and a process for preparation thereof. Ram Sagar, Mohd Saquib, Arun K. Shaw, Anil N. Gaikwad, Sudhir K Sinha, Anil Srivastava, Vinita Chaturvedi, Manju Y. K. Ranjana Srivastava and B. S. Srivastava. Indian Patent (No. 0533DEL2006) 28.02.2006 (Ref. No. 0210NF2005). (Granted 05-Oct 2013, Patent No. 257469)