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Shailja Singh

Shailja Singh
Shailja Singh
Professor
Centre/School/Special Centre
Special Centre for Molecular Medicine
Room No
3C, GF
Off. Phone
011-26739138
Email
shailjasingh[at]mail[dot]jnu[dot]ac[dot]in
Personal Webpage
https://jnu.ac.in
Qualifications

Ph.D. , University of Delhi, Delhi, India, Biomedical Sciences, 1999 - 2003

M.Sc., Guru Ghasidas Vishwavidyalaya, Chhattisgarh, India, Biotechnology, 1996 - 1998

B.Sc.,,Guru Ghasidas Vishwavidyalaya, Chhattisgarh, India, Biology, 1993 - 1996

Areas of Interest/Specialization

Biomedical Sciences, Malaria, Leishmaniasis, Molecular Parasitology, Molecular Epidemiology and Drug Discovery, Cellular and Molecular Biology, Protein Chemistry.

Experience

Professor, Jawaharlal Nehru University, Delhi, India

Associate Professor, Jawaharlal Nehru University, Delhi, India

Associate Professor, Shiv Nadar University, Delhi-NCR, India.

Innovative Young Biotechnology Fellow, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.

Post-doctoral Fellow, Malaria Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India.

Senior Research Fellow, The Institute of Nuclear Medicine and Allied Sciences (INMAS), Defence Research and Development Organisation (DRDO), New Delhi, India.

Awards & Honours
  1. Serves as an Expert of the Medicines for Malaria Venture (MMV, Switzerland) Expert Scientific Advisory Committee (ESAC).
  2. Member, National Institutes of Health (NIH) - Infectious Diseases Grant Review Committee.
  3. Member, U.S.-Japan Cooperative Medical Sciences Program (USJCMSP)-Grant Evaluation Committee.
  4. Member, Science and Engineering Research Board (SERB)-International Research Experience (SIRE), Department of Science and Technology, Government of India.
  5. Member, Department of Biotechnology-Steering Committee on HRD and Skill Vigyan Programme, Government of India.
  6. Expert member, Technical Expert Committee for Infectious Diseases Biological Programme (TECIDBP), Department of Biotechnology, Government of India.
  7. Programme Expert Member - Prime Minister's Research Fellows (PMRF), Government of India.
  8. Member of National Academy of Sciences India (NASI), Government of India.
  9. External member, Internal Quality Assurance Cell (IQAC), University of Hyderabad, India.
  10. Best Speaker in 14th International Conference on Vectors and vector borne diseases (ICOV 14)-2019, organized by Indian Council of Medical Research (ICMR) and National Academy of Vector Borne Diseases (NAVBD), India.
  11. Special Committee member, School of Life Sciences (SLS), Jawaharlal Nehru University, New Delhi, India.
  12. Member, Council of Scientific and Industrial Research (CSIR)-Associated Laboratory Committee.
  13. Gandhian Young Technology Innovation awards, conferred by Honorable President of India - 2018 (BIRAC-GYTI awards) for the development of engineered E. coli for high-throughput drug screening against Malaria and Kala-azar.
  14. The Women Bioscientist Award - 2018, Department of Biotechnology, Government of India.
  15. Co-investigator award - 2016, NIH International Center of Excellence for Malaria Research in India.
  16. Indus Foundation Award for Research Excellence, 2015.
  17. Shiv Nadar University Award for Excellence in Research, 2013-14.
  18. The Innovative Young Biotechnologist Award (IYBA) - 2013, Department of Biotechnology, Government of India.
  19. INSA International Travel Award to attend World Congress on Drug Discovery and Therapy: Boston, USA, 2013.
  20. Gates Foundation Travel Award to attend Gordon Research Conference on Malaria, Lucca, Italy, 2013.
  21. International Travel Award to attend the Gordon Research Conference on Malaria, Oxford, London, 2009.
  22. Best paper presentation, International Conference on Radiation Damage and its Modification, India, 2002.
  23. Humboldt-Kolleg Travel Award to attend a symposium on Genetics and Human Health, Manipal, India, 2001.
International Collaboration/Consultancy

1. Prof. Dominique Soldati-Favre

Affiliation: Department of Microbiology and Molecular Medicine - Faculty of Medicine, University of Geneva, Switzerland.

2. Dr. Jeremy N Burrows

Affiliation: Head of the Department at Medicines for Malaria Venture (MMV), Switzerland.

3. Dr. Mohandas Narla

Affiliation: Distinguished Scientist, Head, Laboratory of Red Cell Physiology, New York Blood Center (NYBC), New York, United States.

4. Prof. Chetan Chitnis

Affiliation: Head, Malaria Parasite Biology and Vaccines Unit, Institut Pasteur, Paris, France.

5. Prof. Gabriele Pradel

Affiliation: Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Germany.

6. Dr. Gordon Langsley

Affiliation: Laboratory of Comparative Cell Biology of Apicomplexa Parasites, Institut Cochin, Paris, France.

7. Prof. Christoph Arenz

Affiliation: Institut für Chemie der, Humboldt-Universität zu Berlin, Berlin, Germany.

8. Dr. Maxim Shevtsov

Affiliation: Head of the laboratory, Group of Biomedical Nanotechnologies, Institute of Cytology of the Russian Academy of Sciences (RAS), Russia.

Best Peer Reviewed Publications

Papers in peer-reviewed journals (in reverse chronological order; *Corresponding author)

  1. Deepika Kannan, Nishant Joshi, Sonal Gupta, Soumya Pati, Souvik Bhattacharjee, Gordon Langsley & Shailja Singh* (2023) Cytoprotective autophagy as a pro-survival strategy in ART-resistant malaria parasites. Cell Death Discov.;9(1):160. doi: 10.1038/s41420-023-01401-5. (Impact factor: 7.0)
  2. Monika Saini, Che Julius Ngwa, Manisha Marothia, Pritee Verma, Shakeel Ahmad, Jyoti Kumari, Sakshi Anand, Vandana Vandana, Bharti Goyal, Soumyananda Chakraborti, Kailash C. Pandey, Swati Garg, Soumya Pati, Anand Ranganathan, Gabriele Pradel, Shailja Singh* (2023) Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite. Biochem Pharmacol.;212:115567. doi: 10.1016/j.bcp.2023.115567. (Impact factor: 5.8)
  3. Ankita Behl, Rumaisha Shoaib, Fernando De Leon, Geeta Kumari, Monika Saini, Evanka Madan, Vikash Kumar, Harshita Singh, Jyoti Kumari, Preeti Maurya, Swati Garg, Prakash Chandra Mishra, Christoph Arenz, Shailja Singh* (2023) Targeting essential plasmodium cold shock protein to block growth and transmission of malaria parasite. iScience;26(5):106637. doi: 10.1016/j.isci.2023.106637.(Impact factor: 5.8)
  4. Raj Kumar Sah, Sakshi Anand, Waseem Dar, Ravi Jain, Geeta Kumari, Evanka Madan, Monika Saini, Aashima Gupta, Nishant Joshi, Rahul Singh Hada, Nutan Gupta, Soumya Pati, Shailja Singh* (2023) Host-Erythrocytic Sphingosine-1-Phosphate Regulates Plasmodium Histone Deacetylase Activity and Exhibits Epigenetic Control over Cell Death and Differentiation. Microbiol Spectr.;e0276622. doi: 10.1128/spectrum.02766-22. (Impact factor: 3.7)
  5. Geeta Kumari, Ajay Gupta, Raj Kumar Sah, Aryan Gautam, Monika Saini, Aashima Gupta, Akhilesh K Kushawaha, Shailja Singh*, Pijus K Sasmal (2022) Development of Mitochondria Targeting AIE-Active Cyclometalated Iridium Complexes as Potent Antimalarial Agents. Adv Healthc Mater.;e2202411. doi: 10.1002/adhm.202202411. (Impact factor: 10.0)
  6. More KR, Kaur I, Giai Gianetto Q, Invergo BM, Chaze T, Jain R, Huon C, Gutenbrunner P, Weisser H, Matondo M, Choudhary JS, Langsley G, Singh S*, Chitnis CE (2020) Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites. mBio.;11(4):e01287-20. doi: 10.1128/mBio.01287-20.PMID: 32817103 (Impact factor: 6.4)
  7. Jain R., Gupta S., Munde M., Pati S., Singh S* (2020) Development of novel anti-malarial from structurally diverse library of molecules, targeting plant-like Calcium Dependent Protein Kinase 1, a multistage growth regulator of P. falciparum. Biochemical Journal;477(10):1951-1970. doi: 10.1042/BCJ20200045. (Impact factor: 4.1)
  8. Singh P, Alaganan A, More KR, Lorthiois A, Thiberge S, Gorgette O, Guillotte Blisnick M, Guglielmini J, Aguilera SS, Touqui L, Singh S*, Chitnis CE* (2019) Role of a patatin-like phospholipase in Plasmodium falciparum gametogenesis and malaria transmission. Proc Natl Acad Sci U S A.; 116(35):17498-17508. doi: 10.1073/pnas.1900266116. (Impact factor: 11.1)
  9. Kannan D, Yadav N, Ahmad S, Namdev P, Bhattacharjee S, Lochab B, Singh S* (2019).  Pre-clinical study of iron oxide nanoparticles fortified artesunate for efficient targeting of malarial parasite. EBioMedicine; 45: 261-277. doi: 10.1016/j.ebiom.2019.06.026. (Impact factor: 11.1)
  10. Garg S, Agarwal S, Kumar S, Yazdani SS, Chitnis CE, Singh S* (2013). Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites. Nat Commun.;4:1736. doi: 10.1038/ncomms2725. (Impact factor: 16.6)
Recent Peer Reviewed Journals/Books

Book chapters (in reverse chronological order; *Corresponding author)

  1. Iram Irfan, Diksha Shahi, Mukesh C. Joshi, Shailja Singh* and Mohammad Abid*. Emerging Paradigm of Ivermectin and its Hybrids in Elimination of Malaria. Rashid Ali and Shahid ul-Islam (eds.) Chemistry and Biological Activities of Ivermectin, (93–120) © 2023 Scrivener Publishing LLC. In press.
  2. S. Singh* and C.E. Chitnis (2021), "Flow Cytometry-Based Methods for Measurement of Cytosolic Calcium and Surface Protein Expression in Plasmodium falciparum Merozoites", in R. Ménard (ed.), Malaria: Methods and Protocols, ‘Methods in Molecular Biology’ Series [Springer] Vol. 923, Chapter 19, pp. 281-290, DOI 10.1007/978-1-62703-026-7_19
  3. Malabika Chakrabarti , Swati Garg , Akshay Munjal, Sweta Karan, Soumya Pati, Lalit C. Garg and Shailja Singh* (2021), A fast-track phenotypic characterization of Plasmodium falciparum vaccine antigens through Lyse-Reseal Erythrocytes mediated Delivery (LyRED) of RNA interference for targeted translational repression. Methods in Molecular Biology (MiMB): Vaccine Design Methods and Protocols (Publisher: Springer Nature, New York).
  4. Akriti Srivastava, Swati Garg, Sweta Karan, Shikha Kaushik, Anand Ranganathan, Soumya Pati, Lalit C. Garg and Shailja Singh* (2021), Plasmodium falciparum antigen expression in Leishmania parasite: A way forward for live attenuated vaccine development. Methods in Molecular Biology (MiMB): Vaccine Design Methods and Protocols (Publisher: Springer Nature, New York).
  5. S. Singh and C.E. Chitnis (2016), "Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes", in D. Wirth and P. Alonso (ed.), ‘Malaria: Biology in the Era of Eradication’. Cold Spring Harbor Perspectives in Medicine. October 2016
  6. Soumya Pati and Shailja Singh* (2016), Unraveling the role of long noncoding RNAs in pluripotent stem cells-based neuronal commitment and neurogenesis. Regenerative Medicine: Laboratory to Clinic. Springer Science Business Media Singapore Pte Ltd.
  7. Vijeta Sharma, Sonal Gupta, and Shailja Singh* (2017),  Contemporary Approaches for Malaria Drug Discovery. Drug Design: Principles and Applications. Springer Nature Singapore Pte Ltd. 2017. ISBN 978-981-10-5186-9.
  8. Vijeta Sharma, Juveria Khan and Shailja Singh* (2018), Mechanistic and Structural Insights into Oxidative Stress in Malaria and anti-malarial drug metabolism. Oxidative Stress in Microbial Diseases. Springer Nature Singapore Pte Ltd.
  9. Dandugudumula Ramu and Shailja Singh*  (2018), Oxidative Stress:  A boon or bane for Trypanosomatids diseases? Oxidative Stress in Microbial Diseases. Springer Nature Singapore Pte Ltd.
  10. Juveria Khan and Shailja Singh* (2018), Molecular mechanisms of Action and Resistance of Antimalarial drugs. Agricides to Antibiotics,Springer Nature Singapore Pte Ltd.
  11. Amrita Charkrabarty, Vigyasa Singh and Shailja Singh* (2018), Management and control of Antimalarial drug resistance. Agricides to Antibiotics,Springer Nature Singapore Pte Ltd.
Patents (if any)

Patents (if any)