Postdoctoral Research (Immunology): The Cleveland Clinic Ohio, USA
Doctoral Degree (Biotechnoloy): Jadavpur University Kolkata, India
Masters Degree (Microbiology): M.S. University Baroda, India
We work on early host-microbe interactions that ultimately define the predisposition and/or outcomes of diseases. The human epithelium presents the first line of defence against infectious microbes and biofilms. This defence entail extremely complex array of innate immune receptors, signalling cascades and effectors. We investigate these determinants with specific emphasis on the human lung. Here, the type 2 pneumocyte (AT2) and alveolar macrophages cross-talk to coordinate powerful effectors like human beta defensins and cytokines. We have developed a novel Air-liquid-Interface (ALI) model to study these interactions. Concurrently we study their relationships with nosocomial Gram-negative bacterial biofilms with specific emphasis on novel virulence determinants like Quorum signalling and Outer Membrane Vesicles (OMVs). We use high resolution transcriptomics and metabolomics to dissect the interactions between these and human lung innate immunity. These studies help to contribute to the understanding of multiple drug resistant (MDR) nosocomial infections and sepsis, next generation diagnostics, infection control in hospitals and development of novel natural products with anti-biofilm activities. We are currently part of the prestigious National Neonatal Sepsis Research Consortium (DBT), one of the largest research programs in the world in collaboration with AIIMS, TSHTI, IGIB, NII and ICGEB to mitigate sepsis in neonatal babies.
2008 - present ; Assistant Professor, Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India
2009-2012 - Faculty-In-Charge, Mass Spectrometry Laboratory, Advanced Instrumentation Facility, Jawaharlal Nehru University, New Delhi, India
2003-2008 (Feb.) - Faculty Scientist, Indian Institute of Technology, Kharagpur, India
1997-2002 - Postdoctoral Fellow, Department of Immunology & Department of Gastroenterology, The Cleveland Clinic Foundation, USA.
Merlin Bumpus Best Investigator Award, USA, 2001.
Prof. Sanjoy K. Bhattacharya, Bascom Palmer Eye Institute, Florida, U.S.A (Lipidomics).
National Collaborations: The Indian Neonatal Sepsis Consortium (AIIMS-Del, NII, ICGEB, TSHTI, IGIB & IIIT).
1. Lahiri P., Gogoi P., and Ghosh D. (2023) Single-Step Capture and Targeted Metabolomics of Alkyl-Quinolones in Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa. Methods Mol Biol 2625, 201-2016.
2. Pompilio A, Crocetta V, Ghosh D et al. (2016) Stenotrophomonas maltophilia phenotypic and genotypic diversity during a 10-year colonization in the lungs of a cystic fibrosis patient. Frontiers in Microbiology 2016; 7: 1551
3. Pluháček T, Lemr K, Ghosh D, Milde D, Novák J and Havlíček V (2016) Characterization of Microbial Siderophores by Mass Spectrometry. Mass spectrometry Reviews. 35: 35-47
4. Ghosh D., Salzman NH, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Nature. 422:522-6.Commentary: Ganz T. Microbiology: Gut defence. Nature. 422:478-9.
5. Ghosh D., Porter E, Shen B, Lee SK, Wilk D, Drazba J, Yadav SP, Crabb JW, Ganz T, Bevins CL. Paneth cell trypsin is the processing enzyme for human defensin-5. Nat. Immunol. 3:583-590. Commentary: Zasloff M. Trypsin, for the defense. Nat Immunol. 2002 Jun;3(6):508-10.
Ghosh et al.(2025) The Multifactorial Pathobiology of Lipidic Quorum Signaling Molecules of Pseudomonas aeruginosa, in Lipid Analysis in Biology, Health, and Disease
ISBN: 9780443191169 eBook ISBN: 9780443291227 Ghosh, D. (2011). Pathogenesis of Malabsorption Syndrome: Issues on Gut Flora and Innate Immunity. In: Ghoshal (Ed.) Malabsorption Syndrome in Tropics. Delhi: Elsevier. 179-204.
Ghosh, D. (2010). Probiotics and Intestinal Defensins: Augmenting the First Line of Defense in Gastrointentinal Immunity. In Nair, G. B. and Takeda (Ed.), Y. Probiotic Foods in Health and Disease. Delhi: Oxford & IBH Publishing Co. 61-74. ISBN-10 1578086981
1. Selective Detection and Analysis of Small Molecules Ghosh D., Dharware D. and Panchagnula V. Jawaharlal Nehru University, New Delhi and Central Scientific and Industrial Research (CSIR), New Delhi. (Ind) 407/DEL/2011; (EPO) EP2676287A2 ; (USPTO) 20130323849A1. Technology Ready for Transfer.
