Title: Structural And Functional Characterization of Unconventional Myosin from Entamoeba histolytica.
Short Description: Currently, I am working on Myosin of E. histolytica. Myosin Ib , an actin binding protein and the only unconventional myosin motor present in E. histolytica had been found localized to phagocytic cups during early and late stages of phagocytosis. Erythrophagocytosis is one of the best clinical diagnoses for invasive amoebiasis in case of Entamoeba histolytica infection. Thus, detailed structural studies of myosin will be very helpful in understanding the Entamoeba pathogenesis.
Suneeta Junior Research Fellow Email id: suneet53_sls@jnu.ac.in
Title: Structural and functional characterization of crucial signalling pathways in Entamoeba histolytica.
Short Description: Protein phosphorylation/dephosphorylation is an important mechanism in physiology of any organism, including parasitic protozoa. Studying the structure of some of the kinases/phosphatases, subsequently inferring its functional role will help in better understanding of the crucial signalling pathway for survival and invasion process of Entamoeba histolytica. This study will create a platform for the potential anti-parasitic drug discovery against key enzymes of the signalling pathways.
Title: Structural and Functional Characterization of motor domain of Myosin and its regulatory protein from Entamoeba histolytica.
Short Description: Currently, I am working on Myosin I of E. histolytica. Myosin Ib , an motor protein of actin cytoskeleton and the only unconventional myosin motor present in E. histolytica. It had been found localized to phagocytic cups during early and late stages of phagocytosis. Erythrophagocytosis is one of the best clinical diagnoses for invasive amoebiasis in case of Entamoeba histolytica infection. Thus, detailed structural studies of myosin motor domain and its regulatyory protein will be very helpful in understanding the pathogenesis.
Title: Structural and functional relationship of proteins involved in endocytic processes in Entamoeba histolytica.
Khushboo kumari PhD scholar
Title: Structural and functional analyses of enzymes involved in deoxyribonucleotide biosynthesis pathway of helicobacter pylori.
Short Description: I am working on deoxyribonucleotide biosynthesis pathway of helicobacter pylori. Deoxyribonucleotide (dNTPs) synthesis pathway is one of the most essential pathway for the survival of the organism as dNTPs are the building blocks of DNA. The three dimensional structure would be very useful for the in-depth knowledge of the enzymes. Structure based screening for the inhibitors would also be done to disrupt the proliferation and growth of the pathogen through inhibiting this enzyme.
Shalini Mishra Research Scholar Email id: shalinimishra.bhu2017@gmail.com
Title: Structural and functional studies on PH domain containing protein kinases involve in trogocytosis in E. Histolytica.
Abhishek Singh Ph.D Scholar School of Life Sciences, JNU Email id: id:abhish12_sls@jnu.ac.in
Research Interest: Structural biology, Biophysical characterization and
Protein crystallization(CryoEM)
Post Doctoral Fellows
Mohammad Farhan Ali, Ph.D. DST-SERB N-PDF Email id: mohd_farrhan@jnu.ac.in
Title: Structural and functional insights into the serine protease inhibitor of Entamoeba histoytica in amoebic pathogenicity
Short Description:Farhan Ali obtained a Ph.D. at Jamia Millia Islamia (JMI), New Delhi in Biochemistry & Molecular Biology. His research interest involves protein crystallization, molecular biophysics, protein-protein interaction and mechanistic enzymology. Currently his research involves structure determination of Entamoeba histolytica serine protease inhibitor with its congnate protease and also the mechanism of interaction of these proteins during amoebic infection.
Dr. Vijayan Ramachandran SERB Postdoctoral Fellow Email id: rvijayan@jnu.ac.in
Title: Structure-based development of anti-protozoan inhibitors against enzymes involved in cysteine biosynthetic pathway of Entamoeba histolytica.
Research Interests: Computational Chemistry, Molecular Biophysics, BIG Data, etc.
Dr. Danish Idrees D. S. Kothari Post Doctoral Fellow Email id: danish.idress@gmail.com
Title: Investigating Key Residues of Serine Acetyltransferase Responsible For The Structure,
Stability and Function.
Research Interests: Molecular Biology, Molecular Biophysics, Structural Biology, Proteomics,
and Bioinformatics.
Short Description: Currently, I am working as D. S.POST DOCTORAL KOTHARI FELLOW at Jahwarlal Nehru University, India in Structural Biology Lab under the mentor Prof. Samudrala Gourinath. I am interested to understand the 3 D structure of therapeutic proteins and their characterization using crystallographic approach, molecular modeling, protein folding, aggregation and molecular dynamics. Obtained insight of proteins is further utilized for the design of potential drug for the treatment of various diseases.
Amir Zaidi D. S. Kothari Post Doctoral Fellow Email id: azaidi.bio@gmail.com
Title: Structural and Functional Characterization of Protein Phosphatases in Entamoeba histolytica.
Short Description: Kinase and phosphatase have always been an important for drug target as phosphorylation/dephosphorylation of protein is the most common and critical regulatory modification used by cell to control their cellular machinery. I am interested in deciphering the role of uncharacterized protein phosphatases in Entamoeba parasite as well studying the structural aspect of protein. Studies based on phosphatase project are warranted to better understand the role of these enzymes in the regulatory network of E. histolytica and a future prospect of drug target.
Scientists
Dr. Tamanna Anwar SERB - Young Scientist Email id: a.tamanna@yahoo.co.in, tamanna.sls.jnu@gmail.com
Title: Structural and Functional Analysis of Queuine Driven Regulation of Entamoeba histolytica Dnmt2.
Research Interest: Comparative Genomics, Bioinformatics, Structural Biology, Proteomics, Molecular Biology and Microbiology
Short Description: My main research interest lies within systems biology, focused around the use of comparative genomics, structural biology, bioinformatics, molecular biology and microbiology to study the complex biological systems. This includes understanding new mechanisms and genes/proteins involved in interesting processes, especially those that can be potent drug targets against pathogenic diseases and developing web platform for retrieval of the identified data for scientific community.
Dr. Shadab Anwar SERB - Young Scientist
Email Id: shadabanwar25@gmail.com
Title: To Investigate the Role of Oxidant and Antioxidant Enzymes and Its
Association with GSTP1 Polymorphism During Leishmania Infection
Among Kala-azar Endemic Population of Bihar and Jharkhand, India.
Short Description: Currently, I am working on GSTP1 Polymorphism During Leishmania Infection. I have applied a comprehensive and systematic genotype-to-phenotype research strategy to characterize common genetic variation in GSTP1, a gene that encodes a protein that plays diverse roles, from phase II drug metabolism to the regulation of apoptosis. Knowledge of common GSTP1 SNPs and haplotypes, as well as understanding of their functional implications, will contribute both to mechanistic and epidemiologic studies of the involvement of GSTP1 in VL pathogenesis as well as individual variation in response to anti-Leishmania drug therapy.
Lab Assistants
Ved Prakash Project Assistant Email id: vedprakashtr@gmail.com
Short Description: I am currently involved in managing administrative tasks of our laboratory.
