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Anand Ranganathan

Anand Ranganathan

Anand Ranganathan
Anand Ranganathan
Professor
Centre/School/Special Centre
Special Centre for Molecular Medicine
Room No
3E(F)
Off. Phone
26738963
Email
aranganathan@mail.jnu.ac.in
Personal Webpage
https://jnu.ac.in
Qualifications

1992    BSc (Hons) Chemistry    St. Stephen’s College, University of Delhi, India
1994    BA (Tripos) Natural Sciences    Pembroke College, University of Cambridge, UK
1998    PhD (Biochemistry)    Pembroke College, University of Cambridge, UK
1998    MA (Honorary)    Pembroke College, University of Cambridge, UK

Areas of Interest/Specialization

Prof. Ranganathan’s Laboratory has invented codon-shuffling, a novel method for the directed evolution of proteins, using which a de novo protein was unearthed that was able to disrupt ICAM dimerisation and block host cell invasion by both Mycobacterium tuberculosis and Plasmodium falciparum. The major objectives of this research group are as follows:

1. To study the role of host ICAMs in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum.

2. To discover new molecules for TB therapy.

3. To focus on the emergence of Plasmodium falciparum resistance and the repurposing of existing drugs against artemisinin-resistant Plasmodium falciparum.

4. To discover de-novo peptide binders against target proteins of Mycobacterium tuberculosis, Plasmodium falciparum, and Leishmania donovani.

Experience

1998-1999, Post-doctoral fellow    Department of Biochemistry, University of Cambridge, UK
1999-2015, Staff Research Scientist, Recombinant Gene Products Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India
2015-2019, Associate Professor, Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi
2019- , Professor, Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi

Awards & Honours
  • Young Scientist, World Economic Forum, for the New Champions Summit, 2012
  • Young Scientist Medal of the Indian National Science Academy, 2007
  • Young Scientist Medal of the UDCT, India, 2006
  • Associate Fellow, Indian Academy of Sciences, 2003-06
  • Pembroke College Cambridge Scholarship, 1995
  • Cambridge Nehru Centenary Fellowship, 1992
International Collaboration/Consultancy

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Best Peer Reviewed Publications
  1. Chaurasiya, A., Kumari, G., Garg, S., Shoaib, R., Anam, Z., Joshi, N., Kumari, J., Singhal, J., Singh, N., Kaushik, S., Kahlon, AK., Dubey, N., Maurya, MK., Srivastava, P., Marothia, M., Joshi, P., Gupta, K., Saini, S., Das, G., Bhattacharjee, S., Singh, S*., Ranganathan, A*. 2022. Targeting Artemisinin-Resistant Malaria by Repurposing the Anti-Hepatitis C Virus Drug Alisporivir. Antimicrob Agents Chemother. 66(12): e0039222.
  2. Anam, Z., Kumari, G., Mukherjee, S., Rex, DAB., Biswas, S., Maurya, P., Ravikumar, S., Gupta, N., Kushawaha, AK., Sah, RK., Chaurasiya, A., Singhal, J., Singh, N., Kaushik, S., Prasad, TSK., Pati, S., Ranganathan, A.*, Singh, S*. 2022. Complementary crosstalk between palmitoylation and phosphorylation events in MTIP regulates its role during Plasmodium falciparum invasion. Front Cell Infect Microbiol. 12:924424.
  3. Singhal, J*., Madan, E., Chaurasiya, A., Srivastava, P., Singh, N., Kaushik, S., Kahlon, AK., Maurya, MK., Marothia, M., Joshi, P., Ranganathan, A*. and Singh, S*. 2022. Host SUMOylation Pathway Negatively Regulates Protective Immune Responses and Promotes Leishmania donovani Survival. Front. Cell. Infect. Microbiol. 12:878136.
  4. Chaurasiya, A., Garg, S., Khanna, A., Narayana, C., Dwivedi, VP., Joshi, N., Anam, ZE., Singh, N., Singhal, J., Kaushik, S., Kahlon, AK, Srivastava, P., Marothia, M., Kumar, M., Kumar, S., Kumari, G., Munjal, A., Gupta, S., Singh, P., Pati, S., Dag, G., Sagar, R., Ranganathan, A*., Singh, S*. 2021. Pathogen induced subversion of NAD+ metabolism mediating host cell death: a target for development of chemotherapeutics. Cell Death Discov. 7:10.
  5. Anam, ZE., Joshi, N., Gupta, S., Yadav, P., Chaurasiya, A., Kahlon, AK., Kaushik, S., Munde, M., Ranganathan, A*., Singh, S*. 2020. A De novo Peptide from a High Throughput Peptide Library Blocks Myosin A -MTIP Complex Formation in Plasmodium falciparum. Int. J. Mol. Sci. 21(17):6158.
  6. Singh, DK., Dwivedi, VP., Singh, SP., Kumari, A., Sharma, SK., Ranganathan, A., Van Kaer, L., Das, G. 2020. Luteolin-mediated Kv1.3 K+ channel inhibition augments BCG vaccine efficacy against tuberculosis by promoting central memory T cell responses in mice. PLoS Pathog. 16:9.
  7. Ahmad, S., Bhattacharya, D., Kar, S., Ranganathan, A., Van Kaer, L., Das, G. 2019. Curcumin Nanoparticles Enhance Mycobacterium bovis BCG Vaccine Efficacy by Modulating Host Immune Responses. Infect. Immun. 87:11.
  8. Prakash, P., Zeeshan, M., Saini, E., Muneer, A., Khurana, S., Chourasia, BK., Deshmukh, A., Kaur, I., Dabra, S., Singh, N., Anam, Z., Chaurasiya, A., Kaushik, S., Dahiya, P., Kalamuddin, M., Thakur, JK., Mohmmed, A., Ranganathan, A.*, Malhotra, P*. 2017. Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum. Nat Commun. 8(1):1548.
  9. Singh, DK., Dwivedi, VP., Ranganathan, A., Bishai, WR., Kaer, LV., Das, G. 2016. Blockade of the Kv1.3 K+ channel enhances BCG vaccine efficacy by expanding central memory T lymphocytes. J. Infec. Dis. 214, 1456-64.
  10. Bhalla, K., Chugh, M., Mehrotra, S., Rathore, S., Tousif, S., Dwivedi, VP., Prakash, P., Samuchiwal, SK., Kumar, S., Singh, DK., Ghanwat, S., Kumar, D., Das, G., Mohmmed, A., Malhotra, P.*, Ranganathan A*. 2015. Host ICAMs play a role in cell invasion by Mycobacterium tuberculosis and Plasmodium falciparum. Nat Commun. 6:6049.


Total Published Research Articles in National/International Journals: 31

Recent Peer Reviewed Journals/Books
  1. Book, fiction: The Land of the Wilted Rose (Rupa, 2012)
  2. Book, fiction: For Love and Honour (Bloomsbury, 2015)
  3. Fiction: The Rat Eater (Bloomsbury, 2019)
  4. Fiction: Souffle (Penguin, 2023)
  5. Non-fiction: Hindus in Hindu Rashtra (BluOne Ink, 2023)
  6. Non-fiction: India’s Forgotten Scientists (Penguin, 2024 slated).
Patents (if any)

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A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.