Ph. D., School of Life Sciences, JNU
In my laboratory, we use mammalian cells and protozoan parasite as model systems to address questions in the area of 'Molecular Cell biology in Health and Disease'. We have special interest in inter-disciplinary studies at the interface between molecular and cell biology to understand the role of ubiquitin system in the control of cellular functions. The current interests include
(a) regulation of cell cycle and the role of ubiquitin proteasome pathway,
(b) protein quality control mechanisms,
(c) host-pathogen interaction and
(d) unraveling the ubiquitin pathway mediated cellular processes that control the transformation of one development stage to another in protozoan parasites.
2008-Present Assistant Professor, School of Biotechnology, Jawaharlal Nehru University, New Delhi
2005-2008 Lecturer, School of Biotechnology, GGSIP University, Delhi
2004-2005 School of Environmental Sciences, Jawaharlal Nehru University, New Delhi on Department of Science and Technology funded project
2001-2002 Research Associate, Regulation of Protein Function Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, U.S.A.
1996-2000 Visiting Fellow, Laboratory of Immune Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, U.S.A.
2016 Visitors Award for Research constituted by the President of India. Awarded as part of the JNU Molecular Parasitology Group for Best Research by the Honorable President, Shri Pranab Mukherjee at Rashtrapati Bhawan
International Fellowships
1996 - 2000 Fogarty International Visiting Fellowship
1991 - 1996 Senior Research Fellowship, Council for Scientific and Industrial Research, Government of India
1988 - 1990 Junior Research Fellowship, Council for Scientific and Industrial Research, Government of India
Research grants
Research grants have been received from all national granting agencies. Currently running grants are funded by DST (independent grant and DPRP project), and ICMR. Past grants include funding from DBT, DRDO and DST. Funding was also received from DBT-BUILDER, DST-Centre of Excellence in molecular parasitology, DST-PURSE and UPE-II grant.
- Kumari, R., Gupta, P. and Tiwari, S. (2018) Ubc7/Ube2g2 ortholog in Entamoeba histolytica: connection with the plasma membrane and phagocytosis. Parasitol. Res. 117, 1599-1611/ doi 10.1007/s00436-018-5842-6
- Ramanujan, A. and Tiwari, S. (2016) APC/C and Retinoblastoma interaction: Cross-talk of Retinoblastoma protein with the Ubiquitin Proteasome Pathway. Biosci. Rep. 36/ art:e00377 / doi 10.1042/BSR20160152
- Arya, S., Sharma, G., Gupta, P. and Tiwari, S. (2012) In silico analysis of ubiquitin/ubiquitin-like modifiers and their conjugating enzymes in Entamoeba species. Parasitol. Res. 111: 37-51.
- Webster, J. M., Tiwari, S., Weissman, A. M. and Wojcikiewicz, R. J. H. (2003) Inositol 1,4,5-trisphosphate receptor ubiquitination is mediated by mamalian Ubc7, a component of the Endoplasmic Reticulum-Associated Degradation pathway, and is inhibited by chelation of intracellular Zn2+. J. Biol. Chem. 278: 38238-38246.
- Magnifico, A., Ettenberg, S., Yang, C., Mariano, J., Tiwari, S., Fang, F., Lipkowitz, S., and Weissman, A. M. (2003) HECT E3s target Cbl proteins for proteasomal degradation: implications for tyrosine kinase-mediated regulation. J. Biol. Chem. 278: 43169-43177.
- Fang, S., Ferrone, M., Yang, C., Tiwari, S., and Weissman, A. M. (2001) The tumor autocrine motility factor receptor, GP78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA 98: 14422-14427.
- Tiwari, S. and Weissman, A. M. (2001) Endoplasmic Reticulum Associated Degradation (ERAD) of T-cell receptor subunits: Involvement of ER-associated Ubiquitin Conjugating Enzymes (E2s). J. Biol. Chem. 19: 16193-16200.