|Ph. D in Biochemistry, 1995|
A. Cross talk between Energy and Iron metabolism.
B. Iron homeostasis in glial cells: implications in Parkinson’s disease.
C. Role of iron in the growth of Leishmania donovani and in interaction with host macrophages
1994-1997: Postdoctoral Trainee, Postdoctoral Fellow of the American Heart Association of Northeast Ohio, Department of Cell Biology The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. USA.
1998-2001: Research Associate, Department of Cell Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. USA.
2001-2008: Associate Professor, Special Centre for Molecular Medicine, Jawaharlal Nehru University, India.
2008- till date: Professor, Special Centre for Molecular Medicine, Jawaharlal Nehru University
2005- 2007: Chairperson, Special Centre for Molecular Medicine, Jawaharlal Nehru University
1995: INSA medal for young scientist, Indian National Science Academy
1998: Elsa Albrecht Award, USA
2004: International Senior Research Fellowship, The Wellcome Trust, UK
2010: Member of Guha Research Conference
Dr. Paul Fox, Cleveland Clinic Foundation, USA- Posttranscriptional Gene Regulation
Dr. Neena Singh, Case Western Reserve University, USA- Iron in neurodegenerative disorders
I. Mukhopadhyay C.K., Mazumder B., Lindley P.F., and Fox P.L. Identification of the prooxidant site of human ceruloplasmin: A model for oxidative damage by copper bound to protein surfaces. Proc. Natl. Acad. Sci. USA, 94:11546-11551, 1997.
II. Mukhopadhyay C.K., Attieh Z.K. and Fox P.L. Role of ceruloplasmin in cellular iron uptake. Science. 279: 714-717, 1998.
III. Mukhopadhyay C.K., Mazumder B., and Fox P.L. Role of Hypoxia Inducible Factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J. Biol. Chem. 275: 21048-21054, 2000.
IV. Seshadri V., Fox P.L. and Mukhopadhyay C.K. Dual role of insulin in transcriptional regulation of the acute phase reactant ceruloplasmin. J Biol Chem. 277: 27903-27911, 2002
V. Biswas S., Gupta M.K., Chattopadhyay D., and Mukhopadhyay C.K. Insulin induced activation of hypoxia inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase. Am. J. Physiol. Heart and Circulatory Physiology 292(2):H758-66, 2007
I. Das D, Tapryal N, Goswami SK, Fox PL, and Mukhopadhyay CK. Regulation of Ceruloplasmin in human hepatic cells by redox active copper: Identification of a novel AP-1 site in ceruloplasmin gene. Biochem J. 402(1):135-41, 2007
II. Das NK, Biswas S, Solanki S, Mukhopadhyay CK. Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth. Cellular Microbiology 11:83-94, 2009.
III. Tapryal N, Mukhopadhyay C, Das D, Fox PL, Mukhopadhyay CK. Reactive oxygen species regulate ceruloplasmin by a novel mRNA decay mechanism involving its 3-untranslated region: Implications in neurodegenerative diseases. J Biol Chem. 284:1873-83, 2009