Sneha Sudha Komath
Professor
Centre/School/Special Centre
School of Life Sciences
Room No
406
Off. Phone
011-26704502
Email
sskomath@mail.jnu.ac.in
Personal Webpage
Qualifications
Ph.D. University of Hyderabad (Hyderabad), India - 1999
M.Sc. (Chem.) University of Hyderabad (Gold Medalist) - 1991
Areas of Interest/Specialization
Glycobiology/ Biophysical Chemistry
Experience
2014-present Professor, School of Life Sciences, JNU
2008-2014 Associate Professor, School of Life Sciences, JNU
2003-2008 Assistant Professor, School of Life Sciences, JNU
1999-2002 Lecturer, Department of Chemistry, Panjab University, Chandigarh
2001-2002 Research Associate, University of Wisconsin, Madison, USA (on leave from PU).
1998-1999 Research Associate, Institute of Microbial Technology, Chandigarh.
1993-1998 UGC-JRF/SRF, School of Chemistry, University of Hyderabad.
1991-1993 UGC-JRF, SSCU, Indian Institute of Science, Bangalore.
Awards & Honours
National Women Bioscientist Award, 2010
Best Peer Reviewed Publications
- Komath SS. To each its own: Mechanisms of cross-talk between GPI biosynthesis and cAMP-PKA signaling in Candida albicans versus Saccharomyces cerevisiae. J Biol Chem. 2024 Jul;300(7):107444. doi: 10.1016/j.jbc.2024.107444. Epub 2024 Jun 4. PMID: 38838772; PMCID: PMC11294708.
- Sethi SC, Bharati M, Kumar Y, Yadav U, Saini H, Alam P, Komath SS*. The ER-Resident Ras Inhibitor 1 (Eri1) of Candida albicans Inhibits Hyphal Morphogenesis via the Ras-Independent cAMP-PKA Pathway. ACS Infect Dis. 2024 Aug 9. doi: 10.1021/acsinfecdis.4c00175. Epub ahead of print. PMID: 39119676.
- Jain P, Garai P, Sethi SC, Naqvi N, Yadav B, Kumar P, Singh SL, Yadav U, Bhatnagar S, Rahul, Puri N, Muthuswami R*, Komath SS*. Modulation of azole sensitivity and filamentation by GPI15, encoding a subunit of the first GPI biosynthetic enzyme, in Candida albicans. Sci Rep. 2019 Jun 11;9(1):8508. doi: 10.1038/s41598-019-44919-4. PMID: 31186458; PMCID: PMC6559964.
- Jain P, Sethi SC, Pratyusha VA, Garai P, Naqvi N, Singh S, Pawar K, Puri N, Komath SS*. Ras signaling activates glycosylphosphatidylinositol (GPI) anchor biosynthesis via the GPI-N-acetylglucosaminyltransferase (GPI-GnT) in Candida albicans. J Biol Chem. 2018 Aug 3;293(31):12222-12238. doi: 10.1074/jbc.RA117.001225. Epub 2018 Jun 15. PMID: 29907567; PMCID: PMC6078447.
- Yadav B, Bhatnagar S, Ahmad MF, Jain P, Pratyusha VA, Kumar P, Komath SS*. First step of glycosylphosphatidylinositol (GPI) biosynthesis cross-talks with ergosterol biosynthesis and Ras signaling in Candida albicans. J Biol Chem. 2014 Feb 7;289(6):3365-82. doi: 10.1074/jbc.M113.528802. Epub 2013 Dec 19. PMID: 24356967; PMCID: PMC3916540.
Recent Peer Reviewed Journals/Books
- Sethi SC, Bharati M, Kumar Y, Yadav U, Saini H, Alam P, Komath SS*. The ER-Resident Ras Inhibitor 1 (Eri1) of Candida albicans Inhibits Hyphal Morphogenesis via the Ras-Independent cAMP-PKA Pathway. ACS Infect Dis. 2024 Aug 9. doi: 10.1021/acsinfecdis.4c00175. Epub ahead of print. PMID: 39119676.
- Komath SS*, Fujita M, Hart GW, Ferguson MAJ, Kinoshita T. Glycosylphosphatidylinositol Anchors. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 4th ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 12. PMID: 35536964.
- Sah SK, Shefali S, Yadav A, Som P, Komath SS*. The caspase-like Gpi8 subunit of Candida albicans GPI transamidase is a metal-dependent endopeptidase. Biochem Biophys Res Commun. 2020 Feb 18:S0006-291X(20)30268-0. doi: 10.1016/j.bbrc.2020.02.008. Epub ahead of print. PMID: 32081427.