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Karunakar Kar

Karunakar Kar

Karunakar Kar
Karunakar Kar
Associate Professor
Centre/School/Special Centre
School of Life Sciences
Off. Phone
4517
Email
kkar@mail.jnu.ac.in, karunakarkar@gmail.com
Personal Webpage
Karunakar Kar's Google Scholar Page
Qualifications
Ph.D.
Areas of Interest/Specialization

BIOPHYSICAL  AND BIOMATERIALS RESEARCH LABORATORY

1.In-born Metabolic Diseases 
2.Protein Biophysics,
3.Amyloids and Collagen associated diseases. 
4.Rationally Engineered Biomaterials and Nanoparticles.

Experience

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Awards & Honours

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International Collaboration/Consultancy

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Best Peer Reviewed Publications

  1. Prajapati. K.P., Mittal S., Ansari, M., Mahato, O.P., Mishra, N., Tiku, A.B., Anand, B.G., Kar, K. Structural conversion of Serotonin into amyloid-like nanoassembly conceptualizes an unexplored neurotoxicity risk, ACS Nano 2024, 18, 50, 34044–34062 (LINK)
  2. Mittal, S., Prajapati, K.P., Joshi K., Ansari M., Mohato O.P., Anand, B.G., Kar, K. Cu(II) specifically disintegrates amyloid nanostructures via direct intercalation into cross-b architecture.   Nano Letters 2024, 24, 32, 9784–9792 [Front Cover Article] (LINK)
  3. Prajapati, K. P., Mittal, S., Ansari, M., Mohato, O. P., Bharti, S., Ahlawat, S., Tiku, A. B., Anand, B. G., Kar, K. Pleiotropic nanostructures built from L-histidine show biologically relevant multi-catalytic activities. ACS Applied Materials and Interfaces:  2024, 16, 18268–18284.(LINK)
  4. Anand B.G., Prajapati K.P., Dubey K., Ahamad N, Shekhawat D.S., Rath P.C., Joseph G.K., Kar K. Self-Assembly of Artificial Sweetener Aspartame Yields Amyloid-Like Cytotoxic Nanostructures. ACS Nano. (2019); 13(5): 6033-6049. (LINK)
  5. Prajapati. K.P, Ansari M., Mittal, S., Anand, B.G., Kar, K. Initiation of Brain Extract Fibrillation and Effective Cellular Internalization of Tryptophan fibrils unveils its neurotoxicity threat. ACS Chemical Neuroscience, 2023, 14, 24, 4274-4281 [Front Cover Article] (LINK)
  6. Ansari M., Prajapati, K.P., Anand, B.G., Chaudhuri, P., Mittal, S., Kar, K. Construction of  Chemoreactive Heterogeneous Nanofibers Through Strategic Co-assembly of Different Proteins Materials Today Nano 2023, 22, 100317 (LINK)
  7. Anand B.G., Prajapati, K.P., Shekhawat, D.S., Kar, K. Tyrosine generated nanostructures initiate amyloid cross-seeding in proteins leading to lethal aggregation trap. Biochemistry. (2018) 57 (35), 5202-5209 (LINK)
  8. Dubey, K., Anand, B.G., Shekhawat, D.S. and Kar, K. Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis. Scientific Reports (2017) 7: 40744
  9. Kar, K., Jayaraman, M., Sahoo, B., Kodali, R., Wetzel, R., Critical nucleus size for disease-related polyglutamine aggregation is repeat length dependent. Nature Structural & Molecular Biology, (2011) 18: 328-336 (LINK)
  10. Misra, P., Kodali, R., Chemuru, S., Kar, K., Wetzel, R. Rapid alfa-oligomer formation mediated by the Abeta C-terminus initiates an amyloid assembly pathway. Nature Communication (2016) 7:12419
  11. Kar, K., Amin, P., Bryan, M.A., Persikov, A.V., Mohs, A., Wang, Y.H., Brodsky, B., Self- association of collagen triple helical peptides into higher order structures. Journal of Biological Chemistry (2006) 281:33283-33290. 
  12. Kar, K., Hoop, C., Baker, M.A., Lengyel, G., Kodali, R., van der Wel, P., Horne, S., Wetzel, R., Backbone engineering within a latent ß-hairpin structure to design inhibitors of polyglutamine amyloid formation. Journal of Molecular Biology (2016) 429(2):308-323. 
Recent Peer Reviewed Journals/Books
  1. Anand, B.G., Prajapati. K.P., Ansari, M., Yadav, D. K., Temgire, M., Kar, K.* The genesis of neurotoxic hybrid nanofibers from the co-assembly of aromatic amino acids. ACS Applied Materials & Interfaces. 2021; 13, 31, 36722–36736
  2. Prajapati. K.P., Anand, B.G., Temgire, M., Tiku, A.B., Kar, K.* Amyloid-mimicking toxic nanofibers generated via self-assembly of dopamine Nanoscale 2022, 14, 8649 – 8662
  3. Ansari M., Prajapati, K.P., Mittal S., Anand, B.G,, Mishra, N., Anand, B., Kar, K.* Sequence Independent Rapid Co-aggregation of Proteins: Possible Role of Conformational Complementarity: Biochemistry  2024, 63, 2977–2989 (Front Cover Article)
  4. Anand, B.G., Dubey, K., Singh, D.S, Prajapati, K.P.,  Kar, K.*, Strategically desinged anitifibrotic gold nanoparticles to prevent collagen fibrill formation, Langmuir (2017) 33: 13252-13261
  5. Anand, B.G., Dubey, K., Singh, D., Kar, K.*, Capsaicin coated silver nanoparticles inhibit amyloid fibril formation of serum albumin, Biochemistry (2016) 55: 3345-3348
  6. Dubey, K., Bibin G. Anand, Temgire, M., Kar, K*. Evidence of coaggregation globular proteins during amyloid formation. Biochemistry, (2014) 53:8001-8004
  7. Hoop, C.L., Lin, H.K., Kar, K., Magyarfalvi, G., Lamley, J.M., Boatz, J.C., Lewandowski, J.R., Wetzel, R., van der Wel, P.C. Huntingtin exon 1 fibrils feature an interdigitated ß-hairpin–based polyglutamine core. Proceedings of the National Academy of Sciences (2016) 113:1546-1551
Patents (if any)

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A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.