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Vijay Pal Singh Rawat

Vijay Pal Singh Rawat

Vijay Pal Singh Rawat
Vijay Pal Singh Rawat
Associate Professor
Centre/School/Special Centre
Special Centre for Molecular Medicine
Room No
3E (GF)
Off. Phone
011-26738735
Email
vijaypsrawat@mail.jnu.ac.in, rawatcdx@gmail.com
Personal Webpage
https://jnu.ac.in
Qualifications

Ph.D in Human Biology,  (Summa cum laude),  2006.
Ludwig - Maximilians – University (LMU), Munich, Germany

Areas of Interest/Specialization

Blood Cancer, Normal Stem Cell and Cancer Stem Cell and Hematopoiesis

  • Genetics, Epigenetics, Homeobox Genes and Small non-coding RNA
  • Establishing in vitro assays and in vivo cancer models (syngeneic and xenograft) for cancer initiation, development and drug screening
  • Gene knockdown or knockout in cancer cell lines and primary samples using lentivirus based shRNA or CRISPR/CAS9 methods
Experience

Jan, 2007- Aug, 2009    Junior group leader, Clinical Co-operative Group (CCG) Leukemia, Klinikum Grosshadern, LMU, Munich, Germany.

Sept, 2009 - May, 2010  Junior group leader, Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm (CCCU), University Hospital Ulm, Germany

June, 2010 – May 2016  Assistant Professor, University of Ulm, Comprehensive Cancer Center Ulm (CCCU),  Germany.

July, 2016 – June 2020  Senior Scientist, Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm (CCCU), University Hospital Ulm, Germany

July, 2020 – Dec 2020   Principal Scientist, Institute of Experimental Cancer Research, Comprehensive Cancer Center Ulm (CCCU), University Hospital Ulm, Germany

Jan 2021 – till date       Associate Professor, at the  Special Centre for Molecular  Medicine, Jawaharlal Nehru University, New Delhi-110067

Awards & Honours

Young Master Award, German/Swiss/Austrian Society of Hematology and Oncology (DGHO/SGH/ASHO), Basel, Switzerland, 2003

Selected for Young Investigator Award,  International Society for Experimental Hematology (ISEH), New Orleans, USA, 2004

Best Thesis Award, Helmholtz Center Munich for Environmental & Health, Munich. Germany, 2008

Travel Award, American Society of Hematology (ASH),  USA,  2003, 2006 and 2007. ISEH travel award,  Melbourne, Australia, 2010.

Young investigator award, International Conference on Stem Cells and Cancer, New Delhi, India, 2012

International Collaboration/Consultancy

Prof. Dr. med. Christian Buske, Director, Institute of Experimental Cancer Research,  Albert-Einstein-Allee 11, 89081 Ulm, Germany

Prof. Dr. med. Michaela Feuring,  Department of Internal Medicine III, Ulm University, Albert-EinsteinAllee 23, 89081 Ulm, Germany

Best Peer Reviewed Publications

  1. Bamezai S, Pulikkottil AJ, Yadav T, Naidu VM, Mueller J, Mark J, Mandal T, Feder KA, Lehle S, Song C, Rosler R, Wiese S, Hoell JI, Kloetgen A, Karsan A, Kumari A, Wojenski L, Sinha AU, Gonzalez-Menendez I, Quintanilla-Martinez L, Donato E, Trumpp A, Kruse E, Hamperl S, Zou L, Rawat VPS *, Buske C*. A non-canonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML. Blood, 6;142(1):90-105.  July 2023.  (IF: 25)
  2. Pulikkottil AJ  Bamezai S, Ammer T, Mohr F, Feder K, Vegi NM, Mandal T, Kohlhofer U,  Quintanilla-Martínez L, Singh A, Buske C*, Rawat VPS*. TET3 promotes AML growth and epigenetically regulates glucose metabolism and leukemic stem cell associated pathways. Leukemia, Aug. 2021.
  3. Bamezai S, Demir D, Pulikkottil A, Ciccarone F, Fischbein E, Sinha A, Borga C, Kronnie Gt, Meyer LH, Mohr F, Götze M, Caiafa P, Debatin KM, Döhner K, Döhner H, Menendez I, Quintanilla-Martínez L, Herold T, Jeremias I, Feuring-Buske M, Buske C*, Rawat VPS*. TET1 acts as pro-leukemic factor in human T-cell acute lymphoblastic leukemia and can be antagonized via PARP inhibition. Leukemia,;35(2):389-403, Feb. 2021.
  4. Rawat VPS*≠, Götze M≠, Rasalkar A, Vegi NM, Ihme S, Thoene S, Pastore A, Bararia D, Döhner H, Döhner K, Feuring-Buske M, Quintanilla-Fend L, Buske C*. The microRNA miR-196b acts as tumor suppressor in Cdx2 driven acute myeloid leukemia. Haematologica.;105(6):e285-e289  Jun. 2020
  5. Thoene S, Mandal T, Vegi NM, Quintanilla-Martinez L, Rösler R, Wiese S, Metzeler KH, Herold T, Haferlach T, Döhner K, Döhner H,  Schwarzmüller L, Klingmüller U, Buske C, Rawat VPS*, Feuring-Buske M*. The ParaHox gene Cdx4 induces acute erythroid leukemia in mice. Blood Adv. 26;3(22):3729-3739Nov.  2019
  6. Rawat VPS*, Arseni N*, Farid A Mulaw MA, Thoene S, Heilmeier B, Sadlon T, D’Andrea RJ, Bohlander SK, Hiddemann W, Buske C, Feuring-Buske M. The Vent-like homeobox gene VENTX promotes human myeloid development in vitro and in vivo and is highly expressed in acute myeloid leukemia. PNAS, 28;107(39):16946-51, Sep. 2010
  7. Rawat VPS*, Thoene S*, Heilmeier B, Hoster E, Metzeler K., Herold T, Hiddemann W, Gökbuget N. Hoelzer D. Bohlander SK,  Feuring-Buske M, Buske C. The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia. Leukemia,;23(4):649-55 Apr. 2009
  8. Rawat VP, Thoene S, Naidu V, Arseni N., Heilmeier B, Metzeler K, Petropoulos K, Deshpande AJ, Bohlander SK, Quintanilla-Martinez L, Spiekermann K, Hiddemann W, Feuring-Buske M, Buske C. Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia. Blood, 1;111(1):309-19 Jan. 2008
  9. Deshpande AJ, Cusan M, Rawat VP, Reuter H, Krause A, Pott C, Quintanilla-Martinez L, Kakadia P, Kuchenbauer F, Ahmed F, Delabesse E, Hahn M, Lichter P, Kneba M, Hiddemann W, Macintyre E, Mecucci C, Ludwig WD, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia. Cancer Cell,;10(5):363-74. Nov. 2006
  10. Rawat VP, Cusan M, Deshpande A, Hiddemann W, Quintanilla-Fend L, Humphries RK, Bohlander SK, Feuring-Buske M, Buske C. Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia. PNAS, 101:817-822. 2004
Recent Peer Reviewed Journals/Books

Total Published Research Articles in International Journals: 23

Published Abstracts in International Journals: 36

A warm welcome to the modified and updated website of the Centre for East Asian Studies. The East Asian region has been at the forefront of several path-breaking changes since 1970s beginning with the redefining the development architecture with its State-led development model besides emerging as a major region in the global politics and a key hub of the sophisticated technologies. The Centre is one of the thirteen Centres of the School of International Studies, Jawaharlal Nehru University, New Delhi that provides a holistic understanding of the region.

Initially, established as a Centre for Chinese and Japanese Studies, it subsequently grew to include Korean Studies as well. At present there are eight faculty members in the Centre. Several distinguished faculty who have now retired include the late Prof. Gargi Dutt, Prof. P.A.N. Murthy, Prof. G.P. Deshpande, Dr. Nranarayan Das, Prof. R.R. Krishnan and Prof. K.V. Kesavan. Besides, Dr. Madhu Bhalla served at the Centre in Chinese Studies Programme during 1994-2006. In addition, Ms. Kamlesh Jain and Dr. M. M. Kunju served the Centre as the Documentation Officers in Chinese and Japanese Studies respectively.

The academic curriculum covers both modern and contemporary facets of East Asia as each scholar specializes in an area of his/her interest in the region. The integrated course involves two semesters of classes at the M. Phil programme and a dissertation for the M. Phil and a thesis for Ph. D programme respectively. The central objective is to impart an interdisciplinary knowledge and understanding of history, foreign policy, government and politics, society and culture and political economy of the respective areas. Students can explore new and emerging themes such as East Asian regionalism, the evolving East Asian Community, the rise of China, resurgence of Japan and the prospects for reunification of the Korean peninsula. Additionally, the Centre lays great emphasis on the building of language skills. The background of scholars includes mostly from the social science disciplines; History, Political Science, Economics, Sociology, International Relations and language.

Several students of the centre have been recipients of prestigious research fellowships awarded by Japan Foundation, Mombusho (Ministry of Education, Government of Japan), Saburo Okita Memorial Fellowship, Nippon Foundation, Korea Foundation, Nehru Memorial Fellowship, and Fellowship from the Chinese and Taiwanese Governments. Besides, students from Japan receive fellowship from the Indian Council of Cultural Relations.